2. Academic Validation
  3. Flavonoids, alkaloids from the seeds of Crotalaria pallida and their cytotoxicity and anti-inflammatory activities

Flavonoids, alkaloids from the seeds of Crotalaria pallida and their cytotoxicity and anti-inflammatory activities

  • Phytochemistry. 2017 Nov;143:64-71. doi: 10.1016/j.phytochem.2017.07.010.
Xiu-Ren Hu 1,  Gui-Xin Chou 2,  Cheng-Gang Zhang 1
Affiliations

Affiliations

  • 1 The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China; Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201203, People's Republic of China.
  • 2 The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China; Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201203, People's Republic of China. Electronic address: chouguixinzyb@126.com.
PMID: 28777979 DOI: 10.1016/j.phytochem.2017.07.010
Abstract

Three Flavonoids, cropalliflavones A-C, including two homoisoflavonoids with rare skeletons; three previously undescribed Alkaloids, usaramine-N-oxide and cropallins A-B; and sixteen known compounds, were isolated from the seeds of Crotalaria pallida Ait. The absolute configurations of cropalliflavone A and usaramine-N-oxide were established by an ECD calculation and X-ray crystallography, respectively. Additionally, cropalliflavone B showed anti-proliferative activity against the MCF-7 cell line with an IC50 value of 6.77 μM, and cropalliflavone C showed anti-inflammatory activity, with an IC50 value of 16.07 μM.

Keywords

Alkaloid; Anti-inflammation; Crotalaria pallida (Leguminosae); Cytotoxicity; Homoisoflavonoid.

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