2. Academic Validation
  3. Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1

Two New Succinimide Derivatives Cladosporitins A and B from the Mangrove-derived Fungus Cladosporium sp. HNWSW-1

  • Mar Drugs. 2018 Dec 20;17(1):4. doi: 10.3390/md17010004.
Pei Wang 1 2,  Yan Cui 3 4,  Caihong Cai 5 6,  Huiqin Chen 7 8,  Yu Dai 9 10,  Pengwei Chen 11 12,  Fandong Kong 13 14,  Jingzhe Yuan 15 16,  Xinming Song 17,  Wenli Mei 18 19,  Haofu Dai 20 21
Affiliations

Affiliations

  • 1 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. wangpei@itbb.org.cn.
  • 2 Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China. wangpei@itbb.org.cn.
  • 3 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. cuiyan502@163.com.
  • 4 Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China. cuiyan502@163.com.
  • 5 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. caicaihong@itbb.org.cn.
  • 6 Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China. caicaihong@itbb.org.cn.
  • 7 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. chenhuiqin@itbb.org.cn.
  • 8 Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China. chenhuiqin@itbb.org.cn.
  • 9 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. daiyu15@mails.ucas.ac.cn.
  • 10 Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China. daiyu15@mails.ucas.ac.cn.
  • 11 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. chenpengwei@itbb.org.cn.
  • 12 Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China. chenpengwei@itbb.org.cn.
  • 13 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. kongfandong@itbb.org.cn.
  • 14 Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China. kongfandong@itbb.org.cn.
  • 15 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. yuanjingzhepc@126.com.
  • 16 Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China. yuanjingzhepc@126.com.
  • 17 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education and Hainan Normal University, Haikou 571101, China. sxm8646@163.com.
  • 18 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. meiwenli@itbb.org.cn.
  • 19 Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China. meiwenli@itbb.org.cn.
  • 20 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. daihaofu@itbb.org.cn.
  • 21 Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Haikou 571101, China. daihaofu@itbb.org.cn.
PMID: 30577517 DOI: 10.3390/md17010004
Abstract

Two new succinimide-containing derivatives, cladosporitins A (1) and B (2), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with a new pyrone, clapone (3), as well as the previously reported talaroconvolutin A (4) and anthraquinone (5). The structures of the isolated compounds were elucidated by 1D, 2D NMR, and HRMS spectral analysis. Compound 2 showed cytotoxicity against BEL-7042, K562 and SGC-7901 cell lines with IC50 values of 29.4 ± 0.35 μM, 25.6 ± 0.47 μM, and 41.7 ± 0.71 μM, respectively, whereas compound 4 exhibited cytotoxicity against Hela and BEL-7042 cell lines with IC50 values of 14.9 ± 0.21 μM and 26.7 ± 1.1 μM, respectively. In addition, compounds 4 and 5 displayed inhibitory activity against α-glycosidase, with IC50 values of 78.2 ± 2.1 μM and 49.3 ± 10.6 μM, respectively.

Keywords

Cladosporium sp.; cytotoxicity; mangrove-derived fungus; succinimide-containing derivatives; α-glycosidase inhibitor.

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