1. Academic Validation
  2. Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis

Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis

  • Phytochemistry. 2021 Nov;191:112910. doi: 10.1016/j.phytochem.2021.112910.
Mengsha Wei 1 Peng Zhou 1 Liping Huang 1 Jie Yin 1 Qin Li 1 Chong Dai 1 Jianping Wang 1 Lianghu Gu 2 Qingyi Tong 3 Hucheng Zhu 4 Yonghui Zhang 5
Affiliations

Affiliations

  • 1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • 2 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: gulianghu@hust.edu.cn.
  • 3 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: qytong@hust.edu.cn.
  • 4 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: zhuhucheng@hust.edu.cn.
  • 5 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: zhangyh@mails.tjmu.edu.cn.
Abstract

Ten sesterterpenoids, including eight undescribed ones named spectanoids A-H and two known analogs, were obtained from Aspergillus spectabilis. Their structures, including absolute configurations, were determined based on HRESIMS, NMR, ECD calculations and single-crystal X-ray diffraction analyses. Spectanoids A-G are tricyclic sesterterpenoids with an unusual 5/12/5 ring system, while spectanoid H possesses a 5/8/6/5 ring system. All of these compounds were evaluated for their cytotoxic activities against three human Cancer cells, and spectanoid A, spectanoid C and spectanoid F exhibited moderate cytotoxic activities with IC50 values ranging from 12.1 to 26.1 μM.

Keywords

Aspergillaceae; Aspergillus spectabilis; Cytotoxic activities; Sesterterpenoids.

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