2. Academic Validation
  3. A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis

A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis

  • J Nat Prod. 2022 Apr 22;85(4):1109-1117. doi: 10.1021/acs.jnatprod.1c01231.
Xiangjie Chen 1,  Qiuyu Wu 1,  Zheng Gong 1,  Tengfei Ren 1,  Qian Du 1,  Yukang Yuan 1,  Yibo Zuo 1,  Ying Miao 1,  Jiuyi He 1,  Caixia Qiao 1,  Zhijin Zheng 1,  Tingting Zhang 1,  Lin Huang 2,  Zhijun Xie 2,  Jun Wang 3,  Yueping Zhu 4,  Chuanwu Zhu 4,  Yang Xu 5,  Depei Wu 5,  Fangyuan Gong 1,  Junping Cheng 4,  Chengping Wen 2,  Hui Zheng 1
Affiliations

Affiliations

  • 1 Institutes of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, China.
  • 2 College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
  • 3 Department of Intensive Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215123, China.
  • 4 The Affiliated Infectious Diseases Hospital of Soochow University, Suzhou 215000, China.
  • 5 Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215123, China.
PMID: 35302365 DOI: 10.1021/acs.jnatprod.1c01231
Abstract

Rheumatoid arthritis (RA) is an autoimmune disease with nearly 1.6 billion patients worldwide and an incidence of 0.5-1%. In recent years, basic and clinical studies have revealed that immune cell responses and corresponding secretion of inflammatory factors are important in the control of RA development. Our study found that a natural plant ingredient, menthone, could be used as a potential antirheumatism compound. In vivo observations demonstrated that menthone alleviates collagen II-induced arthritis (CIA) in mice. Furthermore, we found that menthone regulates the number of Th1 and Th17 cells in CIA mice. Importantly, menthone significantly inhibits the release of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, in CIA mice. Our study suggests a potential component for the development of drugs to treat rheumatoid arthritis.

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