2. Academic Validation
  3. Methylergometrine antagonizes 5 HT in the temporal artery

Methylergometrine antagonizes 5 HT in the temporal artery

  • Eur J Clin Pharmacol. 1987;33(1):77-9. doi: 10.1007/BF00610384.
P Tfelt-Hansen 1,  I Jansen,  L Edvinsson
Affiliations

Affiliation

  • 1 Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
PMID: 3691600 DOI: 10.1007/BF00610384
Abstract

Methylergometrine, the main metabolite of methysergide, has 40-times greater 5 HT antagonistic potency than methysergide in isolated segments of human temporal artery. It is suggested that methylergometrine is the "active" drug when methysergide is used in migraine prophylaxis, and that the two compounds should be compared in prophylactic trials in migraine.

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