2. Academic Validation
  3. Diastereomers of Steroidal Alkaloids with Cytotoxic Activities against Non-Small-Cell Lung Cancer from the Bulbs of Fritillaria sinica

Diastereomers of Steroidal Alkaloids with Cytotoxic Activities against Non-Small-Cell Lung Cancer from the Bulbs of Fritillaria sinica

  • J Nat Prod. 2024 Feb 23;87(2):252-265. doi: 10.1021/acs.jnatprod.3c00910.
Jia-Yuan Li 1,  Shi-Fei Wu 1,  Ya-Ling An 1 2,  Chang-Liang Yao 1,  Shuai Yao 1,  Wen-Long Wei 1,  Jian-Qing Zhang 1,  Qi-Rui Bi 1,  Dean Guo 1 2
Affiliations

Affiliations

  • 1 National Engineering Research Center of TCM Standardization Technology, Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • 2 University of Chinese Academy of Sciences, Beijing 100049, China.
PMID: 38294199 DOI: 10.1021/acs.jnatprod.3c00910
Abstract

Eleven new steroidal Alkaloids, along with nine known related compounds, were isolated from the bulbs of Fritillaria sinica. Seven pairs of diastereomers were identified, including six and four 20-deoxy cevanine-type steroidal alkaloid diastereomers with molecular weights of 413 and 415, respectively. Structures were elucidated based on spectroscopic data analysis, chemical derivatization, and single-crystal X-ray diffraction analysis. Compounds 5, 9, 11, 12, 16, and 20 exhibited significant in vitro cytotoxic activity against non-small-cell lung Cancer with CC50 values from 6.8 ± 3.9 to 12 ± 5 μM.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z