Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging

Affiliations

• 1 Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, United States.
• 2 Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
• 3 Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
• 4 Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
• 5 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States.
• 6 Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
• 7 Departments of Neuroscience, Behavioral Medicine & Psychiatry, Physiology, and Pharmacology, the Rockefeller Neuroscience Institute, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, United States.
• 8 Department of Anesthesiology, Rutgers, The State University of New Jersey, Newark, New Jersey 07103, United States.
• 9 Department of Surgery, School of Medicine, and Mouse Biology Program, University of California, Davis, 2795 Second Street, Suite 400, Davis, California 95618, United States.