2. Academic Validation
  3. Plant anticancer agents X. Isolation of camptothecin and 9-methoxycamptothecin from Ervatamia heyneana

Plant anticancer agents X. Isolation of camptothecin and 9-methoxycamptothecin from Ervatamia heyneana

  • J Nat Prod. 1979 Sep-Oct;42(5):475-7. doi: 10.1021/np50005a006.
S P Gunasekera,  M M Badawi,  G A Cordell,  N R Farnsworth,  M Chitnis
PMID: 521817 DOI: 10.1021/np50005a006
Abstract

The Anticancer activity of the roots of Ervatamia heyneana (Apocynaceae) was found to be due principally to the known alkaloid, camptothecin (1). The closely related, but less active, 9-methoxycamptothecin (2) was also obtained. This is the first reported isolation of these biogenetically interesting Alkaloids from the indole alkaloid rich Apocynaceae.

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