2. Academic Validation
  3. Anti-HIV pronucleotides: decomposition pathways and correlation with biological activities

Anti-HIV pronucleotides: decomposition pathways and correlation with biological activities

  • Bioorg Med Chem Lett. 1998 May 5;8(9):1045-50. doi: 10.1016/s0960-894x(98)00158-9.
D Egron 1,  I Lefebvre,  C Périgaud,  T Beltran,  A Pompon,  G Gosselin,  A M Aubertin,  J L Imbach
Affiliations

Affiliation

  • 1 Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, France.
PMID: 9871705 DOI: 10.1016/s0960-894x(98)00158-9
Abstract

The purpose of the present study was to compare the decomposition pathways in CEM cell extracts of various phenyl phosphoramidate derivatives of AZT. In addition, the structures of their metabolites were identified. Correlations with their anti-HIV activities in a thymidine kinase deficient (TK-) CEM cell line have been established with a rationale of designing phosphoramidate pronucleotides capable of delivering intracellularly their respective 5'-nucleoside monophosphate derivatives.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z