2. Academic Validation
  3. Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives

Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives

  • Bioorg Med Chem Lett. 1998 May 19;8(10):1267-72. doi: 10.1016/s0960-894x(98)00202-9.
I C Sun 1,  J K Shen,  H K Wang,  L M Cosentino,  K H Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill 27599-7360, USA.
PMID: 9871747 DOI: 10.1016/s0960-894x(98)00202-9
Abstract

Eleven betulin derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Compound 4 was found to be the most active with EC50 and TI values of 0.00066 microM and 21,515, respectively.

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