2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK
  3. Antibody-Drug Conjugates (ADCs) TAM Receptor
  4. Mecbotamab vedotin

Mecbotamab vedotin  (Synonyms: BA3011; CAB-Axl-ADC; CAB-anti-Axl-ADC)

目录号: HY-145622
COA 产品使用指南 技术支持

Mecbotamab vedotin (BA3011) 是一种 pH 依赖性靶向 AXL 的抗体-药物偶联物 (ADC)。Mecbotamab vedotin可以显著抑制 DU145 细胞和 LCLC-103H 细胞中的 AXL 并杀死细胞。Mecbotamab vedotin可用于肺癌、胰腺癌和前列腺癌的研究。抗体部分是 Mecbotamab (HY-P9988)，ADC 毒素分子是 Vedotin (HY-15162)。

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Mecbotamab vedotin

Mecbotamab vedotin Chemical Structure

CAS No. : 2460400-64-8

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1 mg ￥4140
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Mecbotamab vedotin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mecbotamab vedotin (BA3011) is a pH dependent antibody drug conjugate (ADC) targeting AXL. Mecbotamab vedotin can significantly inhibit AXL in DU145 cells and LCLC-103H cells and kills cells. Mecbotamab vedotin can be used for research on cancer such as lung cancer, pancreatic cancer and prostate cancer. The antibody component is Mecbotamab (HY-P9988), and the ADC toxin molecule is Vedotin (HY-15162)[1].

IC50 & Target

AXL; BA301 γ1[1]
体外研究
(In Vitro)

Mecbotamab vedotin (0.1-10000 ng/mL) 在 pH 值 6.0 时在 DU145 细胞 (EC50 = 16 ng/mL)，LCLC-103H 细胞 (EC50 = 37 ng/mL)，293-huAXL (EC50 = 56 ng/mL) 和 293-cynoAXL (EC50 = 20 ng/mL) 中有效结合 AXL[1]。
Mecbotamab vedotin (0.01-10000 ng/mL，3 天) 在 pH 值 6.0 时在 DU145 细胞 (IC50 = 1466 ng/mL) 和 LCLC-103H 细胞 (IC50 = 474 ng/mL) 中表现出显著的细胞毒性，但对 293-F 细胞无毒[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mecbotamab vedotin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: DU145 cells, LCLC-103H cells and 293-F cells
Concentration: 0.01-10000 ng/mL
Incubation Time: 3 days
Result: Significantly killed the DU145 cells (IC50 = 1466 ng/mL) and LCLC-103H cells (IC50 = 474 ng/mL) at pH 6.0.
Effectively killed the DU145 cells (IC50 = 5069 ng/mL) and LCLC-103H cells (IC50 = 1095 ng/mL) at pH 7.4.
Had no significant toxicity to 293-F cells.
体内研究
(In Vivo)

Mecbotamab vedotin (1-6 mg/kg，静脉注射，每 4 天一次，共 6 次) 显著抑制携带 LCLC-103H 肿瘤的雌性 NOD/SCID 小鼠的肿瘤生长[1]。
Mecbotamab vedotin (1-10 mg/kg，静脉注射，每 4 天一次，共 4 次) 显著抑制携带 MIA PaCa-2 肿瘤的雌性 NOD/SCID 小鼠的肿瘤生长[1]。
Mecbotamab vedotin (6-15 mg/kg，静脉注射，每 4 天一次，共 6 次) 显著延迟了携带 DU145 肿瘤的雄性 BALB/c 裸鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×106 LCLC-103H cells injected female NOD/SCID mice[1]
Dosage: 1, 3 and 6 mg/kg
Administration: Intravenous injection (i.v.), once every 4 days, for 6 times
Result: Significantly inhibited tumor growth (TGI range of 114-115%) and the efficacy of the 3 and 6 mg/kg groups persisted until 57 days.
Animal Model: 1×106 MIA PaCa-2 cells injected female NOD/SCID mice[1]
Dosage: 1, 3, 6 and 10 mg/kg
Administration: Intravenous injection (i.v.), once every 4 days, for 4 times
Result: Resulted in a TGI of 59% in the 6 mg/kg group and complete tumor regression in the 10 mg/kg group.
Animal Model: 5×106 DU145 cells injected female NOD/SCID mice[1]
Dosage: 6, 10 and 15 mg/kg
Administration: Intravenous injection (i.v.), once every 4 days, for 6 times
Result: Showed persistent anti-tumor activity in the 10 and 15 mg/kg groups.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C, protect from light
纯度 & 产品资料
参考文献

Mecbotamab vedotin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mecbotamab vedotin2460400-64-8BA3011 CAB-Axl-ADC CAB-anti-Axl-ADCBA 3011BA-3011Antibody-Drug Conjugates (ADCs)TAM ReceptorAntibody-Drug ConjugatesTyro3AxlMerADCAKLcancerDU145LCLC-103HMIA PaCa-2Inhibitorinhibitorinhibit

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目录号：
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