2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Methacholine bromide

Methacholine bromide  (Synonyms: Acetyl-β-methylcholine bromide)

目录号: HY-A0083B
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Methacholine (Acetyl-β-methylcholine) bromide 是一种有效的 muscarinic-3 (M3) 激动剂。Methacholine bromide 直接作用于平滑肌上的乙酰胆碱受体，导致支气管收缩和气道变窄。Methacholine bromide 对识别支气管高反应性 (BHR) 显示出高灵敏度。Methacholine bromide 可用于测量气道高反应性 (AHR)，作为评估具有哮喘样症状和正常静息呼气流速的个体的诊断辅助[2]。

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Methacholine bromide Chemical Structure

Methacholine bromide Chemical Structure

CAS No. : 333-31-3

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Methacholine bromide 的其他形式现货产品:

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Methacholine bromide 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].

体内研究
(In Vivo)

Methacholine bromide (0.5 µg/kg plus 5 µg/kg/min for 30 min) induces bronchoconstriction in dogs[4].
Methacholine bromide (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 µg/kg; i.v.) in a a dose-dependent manner in mouse[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 9-week female BALB/c mice[6]
Dosage: 0.03, 0.1, 0.3, 1 mg/kg
Administration: I.v
Result: Induced severe bronchoconstriction.
Clinical Trial
分子量

240.14

Formula

C8H18BrNO2
CAS 号
中文名称

溴化乙酰甲胆碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Methacholine bromide 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methacholine333-31-3Acetyl-β-methylcholine溴化乙酰甲胆碱mAChRMuscarinic acetylcholine receptorbronchoconstrictionairway hyperresponsivenessasthma-likeInhibitorinhibitorinhibit

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