1. Metabolic Enzyme/Protease
    Autophagy
  2. Endogenous Metabolite
    Cytochrome P450
    Autophagy
  3. Metyrapone Tartrate

Metyrapone Tartrate (Synonyms: Su-4885 Tartrate)

目录号: HY-B1232A
产品使用指南

Metyrapone Tartrate (Su-4885 Tartrate) 是一种有效且具有口服活性的 11β-羟化酶 (11β-hydroxylase) 抑制剂,可抑制醛固酮 (aldosterone)的产生,也是一种细胞自噬 (autophagy) 激活剂。Metyrapone Tartrate 能抑制内源性肾上腺皮质激素的合成,也会影响行为和情绪。此外,Metyrapone Tartrate 可通过下调 mTOR 通路增加自噬过程的效率,也能与恶臭假单胞菌 (Pseudomonas putida) 细胞色素 P-450 (CYP450) 相互作用。Metyrapone Tartrate 可用于研究库兴氏综合征 (Cushing's syndrome) 和抑郁症。

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Metyrapone Tartrate Chemical Structure

Metyrapone Tartrate Chemical Structure

CAS No. : 908-35-0

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  • 生物活性

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  • 参考文献

生物活性

Metyrapone Tartrate (Su-4885 Tartrate) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression[1][2][3][4][5].

IC50 & Target

11β-hydroxylase, Aldosterone, CYP450, Autophagy[1][4][5]

体外研究
(In Vitro)

Metyrapone (100 μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (n=179; 270-300g)[1]
Dosage: 25 or 50 mg/kg (in a volume of 2.0 ml/kg)
Administration: SC, single dosage
Result: Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity.
分子量

526.45

Formula

C22H26N2O13

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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目录号:
HY-B1232A
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