1. MAPK/ERK Pathway
  2. MEK
  3. Mirdametinib

Mirdametinib  (Synonyms: PD0325901; PD325901)

目录号: HY-10254G
产品使用指南

Mirdametinib (PD0325901) (GMP) 是 GMP 级别的 Mirdametinib (HY-10254)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Mirdametinib 是一种具有口服活性,选择性和非 ATP 竞争性的 MEK 抑制剂。

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Mirdametinib Chemical Structure

Mirdametinib Chemical Structure

CAS No. : 391210-10-9

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Mirdametinib 的其他形式现货产品:

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Other Forms of Mirdametinib:

MCE 顾客使用本产品发表的 86 篇科研文献

WB

    Mirdametinib purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2020 Apr 2;524(2):280-287.  [Abstract]

    Western blot analysis of Tcf7l1 protein levels in mESCs pre-treated with D4476 or DMAT and then treated with CHIR or PD03 for 24 h.

    Mirdametinib purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2018 Jun 28;37(1):128.  [Abstract]

    MHCC-97H cells are transfected with control or supervillin-specific siRNA for 48 h, exposed to hypoxia for 16 h, and lysates are assayed for the relative amounts of GTP-loaded (activated) Rac1, Cdc42, and RhoA. Cells that have been transfected with control RNAi are treated with a PD0325901 or SB239063 before assaying for GTP-Rac1, Cdc42, and RhoA levels.

    Mirdametinib purchased from MCE. Usage Cited in: Viruses. 2018 Apr 13;10(4). pii: E191.  [Abstract]

    H2.35 cells are serum starved for 72 h and then are pre-treated with either DMSO or 10 µM PD0325901 (ERK IN). Cells are infected with MP12 (MOI 5) for one hour, followed by removal of viral inoculum, and addition of growth medium containing DMSO or 10 µM ERK IN. At 18 hpi, cell lysates are collected for western blot analysis.

    Mirdametinib purchased from MCE. Usage Cited in: Viruses. 2018 Apr 13;10(4). pii: E191.  [Abstract]

    H2.35 cells are serum starved for 72 h and then were pre-treated with either DMSO or BI-D1870 (p90 IN, 10 µM). Cells are infected with MP12 (MOI 5) for one hour, followed by removal of viral inoculum, and addition of growth medium containing DMSO or p90 IN (10 µM). At 18 hpi, cell lysates are collected for western blot analysis.

    查看 MEK 亚型特异性产品:

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Mirdametinib (PD0325901) (GMP) is Mirdametinib (HY-10254) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Mirdametinib is an orally active, selective and non-ATP-competitive MEK inhibitor[1][2][3].

    体外研究
    (In Vitro)

    Mirdametinib (250 nM; 7 d) 诱导心脏 PCs 分化为血管平滑肌细胞样细胞[1]
    Mirdametinib (10 μM; 4 d) 诱导少突胶质细胞前体细胞 (OPC) 向少突胶质细胞 (OL) 分化[2]
    Mirdametinib 通过关键调控基因和胚胎干细胞特异性 miRNA 增强胚胎干细胞 (ESC) 的自我更新能力,进而影响 ESC 的自我更新和细胞分化[3]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    分子量

    482.19

    Formula

    C16H14F3IN2O4

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献

    Mirdametinib 相关分类

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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