1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. MEK
  4. MEK Inhibitors

MEK Inhibitors

MEK1

MEK2

MEK5

MEK

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

MEK Inhibitors, Antagonists & Activators
Product Name MEK1 MEK2 MEK5 MEK Purity
Trametinib
MEK1, IC50: 2 nM
MEK2, IC50: 2 nM
    99.47%
PD98059
MEK1, IC50: 2-7 μM
MEK2, IC50: 50 μM
    99.96%
Mirdametinib
MEK1, Ki: 1 nM
MEK2, Ki: 1 nM
 
MEK, IC50: 0.33 nM
99.95%
U0126-EtOH
MEK1, IC50: 70 nM
MEK2, IC50: 60 nM
    99.41%
Selumetinib
MEK1, IC50: 14 nM
   
MEK, IC50: 12 nM
99.87%
Isorhamnetin (Standard)
MEK1
     
Cobimetinib
MEK1, IC50: 4.2 nM
      99.73%
Binimetinib      
MEK, IC50: 12 nM
99.50%
Isorhamnetin
MEK1
      99.95%
C16-PAF      
MEK
99.48%
Trametinib (DMSO solvate)
MEK1, IC50: 2 nM
MEK2, IC50: 2 nM
    99.74%
U0126
MEK1, IC50: 70 nM
MEK2, IC50: 60 nM
    98.45%
Avutometinib      
MEK, IC50: 160 nM
98.99%
Lidocaine      
MEK
99.96%
Pimasertib
MEK1
MEK2
    99.88%
CI-1040
MEK1, IC50: 17 nM
      99.86%
BIX02189    
MEK5, IC50: 1.5 nM
  99.99%
trans-Zeatin      
MEK
99.83%
GDC-0623
MEK1, Ki: 0.13 nM (+ATP)
      99.15%
Lidocaine hydrochloride      
MEK
99.96%
Refametinib
MEK1, IC50: 19 nM
MEK2, IC50: 47 nM
    99.82%
TAK-733      
MEK, IC50: 3.2 nM
99.48%
MS432
MEK1, DC50: 31 nM (in HT29 cells)
MEK1, DC50: 31 nM (in SK-MEL-28 cells)
MEK2, DC50: 17 nM (in HT29 cells)
MEK2, DC50: 9.3 nM (in SK-MEL-28 cells)
    99.78%
AZD8330
MEK1, IC50: 7 nM
MEK2, IC50: 7 nM
    99.14%
BI-847325  
MEK2, IC50: 4 nM
    98.66%
APS-2-79
MEK1
      99.48%
Trametiglue
MEK1
MEK2
    98.58%
RGB-286638
MEK1, IC50: 54 nM
      99.84%
SL327
MEK1, IC50: 180 nM
MEK2, IC50: 220 nM
    ≥98.0%
Lixisenatide
MEK1
MEK2
    99.93%
RO4987655
MEK1, IC50: 5.2 nM
MEK2, IC50: 5.2 nM
    99.26%
GW284543    
MEK5
  99.99%
MAP855
MEK1, IC50: 3 nM
      99.38%
Zapnometinib      
MEK, IC50: 5.7 nM
99.63%
PD318088
MEK1
MEK2
    99.91%
BIX02188    
MEK5, IC50: 4.3 nM
  99.59%
Cobimetinib hemifumarate
MEK1, IC50: 4.2 nM
      99.73%
MEK inhibitor      
MEK
98.35%
PD0325901-O-C2-dioxolane
MEK1
MEK2
    98.76%
PD184161      
MEK, IC50: 10-100 nM
99.38%
Lidocaine (Standard)      
MEK
99.85%
RGB-286638 free base
MEK1, IC50: 54 nM
      98.07%
Hypothemycin
MEK1, Ki: 17 nM
MEK2, Ki: 38 nM
    ≥98.0%
Refametinib (R enantiomer)      
MEK, EC50: 2-15 nM
APS-2-79 hydrochloride
MEK1
     
CHMFL-EGFR-202
MEK1, IC50: 161 nM
      99.75%
E6201
MEK1, IC50: 5.2 nM
     
MEK-IN-6 hydrate      
MEK
MEK/PI3K-IN-2
MEK1, IC50: 352 ± 2 nM
     
PD-334581
MEK1
     
MEK/PI3K-IN-1
MEK1, IC50: 124 ± 11 nM
     
PD 198306      
MEK
Lidocaine hydrochloride hydrate      
MEK
GW284543 hydrochloride    
MEK5
 
MEK-IN-6      
MEK
98.69%
Balamapimod      
MEK
MEK-IN-1      
MEK