2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related Cytoskeleton
  3. Microtubule/Tubulin ADC Payload
  4. MMAF

MMAF  (Synonyms: Monomethylauristatin F)

目录号: HY-15579G
产品使用指南 技术支持

MMAF (Monomethylauristatin F) GMP 是 GMP 级别的 MMAF (HY-15579)。MMAF (Monomethylauristatin F) 是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂，用作抗肿瘤药物。MMAF (Monomethylauristatin F) 广泛用作抗体偶联药物 (ADCs) 的细胞毒性成分，如 Vorsetuzumab mafodotin 和 SGN-CD19A。

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MMAF

MMAF Chemical Structure

CAS No. : 745017-94-1

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规格 是否有货
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Customer Review

Other Forms of MMAF:

MMAF 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A[1][2][3].

IC50 & Target

IC50: 119 nM (Cytotoxicity, Karpas 299 cell), 105 nM (Cytotoxicity, H3396 cell), 257 nM (Cytotoxicity, 786-O cell), 200 nM (Cytotoxicity, Caki-1, cell)[4]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BT-474 GI50
0.24 nM
Compound: 6-OMe, MMAF-OMe
Cytotoxicity against human BT474 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human BT474 cells assessed as cell viability incubated fore 4 days by MTS assay
[PMID: 25431858]
BT-474 IC50
8.8 nM
Compound: MMAF
Cytotoxicity against human BT-474 cells assessed as reduction in cell viability incubated for 96 hrs by XTT assay
Cytotoxicity against human BT-474 cells assessed as reduction in cell viability incubated for 96 hrs by XTT assay
[PMID: 34676042]
H3396 IC50
105 nM
Compound: 39; MMAF
Cytotoxicity against human H3396 cells assessed as cell growth inhibition
Cytotoxicity against human H3396 cells assessed as cell growth inhibition
[PMID: 35072477]
H3396 IC50
105 nM
Compound: 4; MMAF
Cytotoxicity against human H3396 cells assessed as inhibition of cell growth incubated for 96 hrs by Alamar blue assay
Cytotoxicity against human H3396 cells assessed as inhibition of cell growth incubated for 96 hrs by Alamar blue assay
[PMID: 39068862]
HCT-116 IC50
2.88 μM
Compound: 39; MMAF
Cytotoxicity against human HCT-116 cells assessed as reduction inc cell viability
Cytotoxicity against human HCT-116 cells assessed as reduction inc cell viability
[PMID: 35072477]
HL-60 IC50
137 nM
Compound: 39; MMAF
Cytotoxicity against P-gp negative human HL-60 cells assessed as reduction inc cell viability
Cytotoxicity against P-gp negative human HL-60 cells assessed as reduction inc cell viability
[PMID: 35072477]
HT-29 IC50
10 nM
Compound: 39; MMAF
Cytotoxicity against human HT-29 cells assessed as cell growth inhibition
Cytotoxicity against human HT-29 cells assessed as cell growth inhibition
[PMID: 35072477]
MDA-MB-361 GI50
0.21 nM
Compound: 6-OMe, MMAF-OMe
Cytotoxicity against human MDA-MB-361 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human MDA-MB-361 cells assessed as cell viability incubated fore 4 days by MTS assay
[PMID: 25431858]
NCI-N87 GI50
0.44 nM
Compound: 6-OMe, MMAF-OMe
Cytotoxicity against human NCI-N87 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human NCI-N87 cells assessed as cell viability incubated fore 4 days by MTS assay
[PMID: 25431858]
SK-BR-3 IC50
5.3 nM
Compound: MMAF
Cytotoxicity against human SKBR3 cells assessed as reduction in cell viability incubated for 96 hrs by XTT assay
Cytotoxicity against human SKBR3 cells assessed as reduction in cell viability incubated for 96 hrs by XTT assay
[PMID: 34676042]
分子量

731.96

Formula

C39H65N5O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MMAF 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMAF (GMP)745017-94-1Monomethylauristatin F (GMP)Microtubule/TubulinADC PayloadADC CytotoxinInhibitorinhibitorinhibit

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目录号：
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