Moroxydine hydrochloride-d₈  (Synonyms: ABOB hydrochloride-d₈)

Moroxydine hydrochloride-d₈ (ABOB hydrochloride-d₈) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels^[1][2][3].

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

215.71

C₆H₆D₈ClN₅O

2469734-82-3

3160-91-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yu XB, et al. Moroxydine (ABOB) hydrochloride hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 2016 Jul;131:156-65.  [Content Brief]

  [2]. Yu XB, et al. In vitro antiviral efficacy of Moroxydine (ABOB) hydrochloride hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus. Dis Aquat Organ. 2016 Oct 27;121(3):189-199.  [Content Brief]

  [3]. Yu XB, et al. Effects of Moroxydine (ABOB) hydrochloride hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation. Res Vet Sci. 2018 Apr;117:37-44.  [Content Brief]