1. Anti-infection Others Apoptosis
  2. Influenza Virus Isotope-Labeled Compounds HCV HSV Apoptosis Caspase
  3. Moroxydine hydrochloride-d8

Moroxydine hydrochloride-d8  (Synonyms: ABOB hydrochloride-d8)

目录号: HY-W713297
产品使用指南 技术支持

Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) 是 Moroxydine (ABOB) hydrochloride (HY-B0420A) 的氘代物。Moroxydine hydrochloride 是一种广谱抗病毒化合物,对 DNA 和 RNA 病毒均具有多重抗病毒活性,包括流感病毒 (influenza virus)、单纯疱疹病毒 (herpes simplex)、水痘-带状疱疹病毒 (varicella zoster)、麻疹病毒 (measles)、腮腺炎病毒 (mumps disease)、丙型肝炎病毒 (hepatitis C virus)等。Moroxydine hydrochloride 对双链 RNA 病毒和大 DNA 病毒感染的细胞展现出卓越的抗病毒效果且细胞毒性较低。Moroxydine hydrochloride 在草鱼肾脏细胞 (CIK) 中能够阻断草鱼呼肠孤病毒 (GCRV) 诱导的细胞病变效应,清除病毒核衣壳,维持细胞正常形态结构。Moroxydine hydrochloride 可显著抑制细胞凋亡 (apoptosis) 过程,具体表现为:降低caspase-3 酶活性、减少 Bax 蛋白表达,同时下调 Bcl-2 水平[1][2][3]

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Moroxydine hydrochloride-d<sub>8</sub> Chemical Structure

Moroxydine hydrochloride-d8 Chemical Structure

CAS No. : 2469734-82-3

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规格 价格 是否有货
1 mg ¥2100
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5 mg ¥5248
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

215.71

Formula

C6H6D8ClN5O

CAS 号
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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