2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation Neuronal Signaling
  3. ELOVL Apoptosis NOD-like Receptor (NLR) Caspase Tau Protein
  4. Mouse Serum Albumin

Mouse Serum Albumin 是血浆中最丰富的蛋白质，当血脑屏障 (BBB) 受损时会渗漏到脑实质中。Mouse Serum Albumin 诱导星形胶质细胞转化为 A1 表型，显著增加 Elovl1 水平。Mouse Serum Albumin 促进极长链脂肪酸 (VLSFAs) 分泌，并通过内质网应激反应途径引发神经元脂质凋亡 (apoptosis)。Mouse Serum Albumin 激活的小胶质细胞通过 NLRP3 炎症体途径显著触发多个位点的 tau 蛋白磷酸化 (Ser202/Thr205)。Mouse Serum Albumin 会降低小鼠的空间学习和记忆能力。Mouse Serum Albumin 可用于研究神经退行性疾病，如阿尔茨海默病 (AD) 和额颞痴呆 (FTD)。

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Mouse Serum Albumin

Mouse Serum Albumin Chemical Structure

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规格 价格 是否有货
20 mg ￥2030
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50 mg ￥3815
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100 mg ￥5355
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Customer Review

Other Forms of Mouse Serum Albumin:

Mouse Serum Albumin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mouse Serum Albumin is most abundant protein in plasma, which leaks into the brain parenchyma when the blood-brain barrier (BBB) is impaired. Mouse Serum Albumin induces astrocytes to A1 phenotype to remarkably increase levels of Elovl1. Mouse Serum Albumin promotes VLSFAs secretion and causes neuronal lippoapoptosis through endoplasmic reticulum stress response pathway. MSA-activated microglia triggeres remarkable tau phosphorylation at multiple sites (Ser202/Thr205) through NLRP3 inflammasome pathway. Mouse Serum Albumin decreases the spatial learning and memory abilities in mice. Mouse Serum Albumin can be used for the study of neurodegenerative diseases like Alzheimer’s disease (AD) and frontotemporal dementia (FTD)[1].

体外研究
(In Vitro)

Mouse Serum Albumin (7 uM, 48 h) 显著减少原代神经元的平均分支长度、终点体视显微镜体素数量和分支数量[1]。
Mouse Serum Albumin (7 uM, 24 h) 在原代星形胶质细胞中上调 Elovl1 mRNA 和蛋白水平[1]。
Mouse Serum Albumin (7 uM, 48 h) 诱导显著的神经元凋亡，在原代神经元中增加 Tunel 阳性细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mouse Serum Albumin 相关抗体:
体内研究
(In Vivo)

Mouse Serum Albumin (每次注射 1 μL，脑室内注射，每 4 天一次，持续 16 天) 损害小鼠的空间学习和记忆能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2-month-old female C57BL/6J mice[1]
Dosage: 1 μL per injection
Administration: Intracerebroventricular injection every 4 days for 16 days
Result: Achieved impaired spatial learning and memory.
Induced increased neuronal apoptosis in hippocampus and neuroinflammation (enhanced microgliosis/astrogliosis, upregulated brain levels of IL-1β, IL-6 and TNF-α).
Promoted tau phosphorylation (increased p-tau at Ser202/Thr205) via activating NLRP3 inflammasome (upregulated NLRP3, ASC, cleaved caspase-1) and downstream IL-1β/IL-18-GSK3β/CaMKIIα pathway.
Downregulated M0 phenotype and phagocytosis-related genes and upregulated MGnD and inflammation-related genes in microglia.
Upregulated A1 astrocyte and inflammation genes and activated VLSFAs elongation pathway in astrocytes.
Downregulated mitochondrial β-oxidation, electron transport and GABA transmission-related genes in neurons.
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mouse Serum Albumin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mouse Serum AlbuminELOVLApoptosisNOD-like Receptor (NLR)CaspaseTau ProteinElongation of Very Long-chain Fatty AcidsElongaseMouse serum albuminNeuroinflammationTau phosphorylationInhibitorinhibitorinhibit

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