2. PROTAC Metabolic Enzyme/Protease Apoptosis
  3. PROTACs Tyrosinase Apoptosis
  4. MS105

MS105 (YX39-105) 是一种具有口服活性和选择性的蛋白酪氨酸激酶 6 (PTK6) PROTAC 降解剂。MS105 通过 VHL 配体片段募集 VHL E3 连接酶，促进 PTK6 泛素化和蛋白酶体降解，抑制乳腺癌细胞增殖、迁移，诱导凋亡 (apoptosis)。MS105 有望用于乳腺癌的研究。(粉色：BRK inhibitor P21d hydrochloride (HY-115514); 黑色：linker (HY-W105727)；蓝色：(S,R,S)-AHPC (HY-125845))。

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MS105 Chemical Structure

MS105 Chemical Structure

CAS No. : 2408339-39-7

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MS105 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MS105 (YX39-105) is an orally active and selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. MS105 recruits VHL E3 ligase via the VHL ligand moiety to promote PTK6 ubiquitination and proteasomal degradation, inhibiting breast cancer cell proliferation, migration, and inducing apoptosis. MS105 is promising for research of breast cancer. (Pink: BRK inhibitor P21d hydrochloride (HY-115514); Black: linker (HY-W105727); Blue: (S,R,S)-AHPC (HY-125845))[1][2].

分子量

1072.30

Formula

C56H70FN13O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MS105 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS1052408339-39-7YX39-105MS 105MS-105PROTACsTyrosinaseApoptosisPTK6PROTACbreast cancerInhibitorinhibitorinhibit

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