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Mycro2 是一种 c-Myc/Max 二聚体和 DNA 结合的抑制剂,抑制 Myc/Max DNA 结合活性的 IC50 值为 23 μM。Mycro2 可以抑制 c- myc 依赖性细胞增殖、基因转录和致癌转化。

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Mycro2 Chemical Structure

Mycro2 Chemical Structure

CAS No. : 314049-21-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mycro2 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 23 μM for the inhibition of Myc/Max DNA binding activity. Mycro2 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation[1].

体外研究
(In Vitro)

Mycro2(10 or 20 μM, 7 days)可以抑制 C-Myc 依赖细胞系 U-2OS、MCF-7、Raji 和 NIH/3T3 的增殖,不会抑制 C-Myc 独立癌细胞株 PC-12 的增殖。Mycro2 在 10 μM 时可以显著抑制 c- myc 诱导的基因转录,在 20 μM 时可以选择性减少 c- myc 转化Rat1a 细胞的非锚定生长[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

408.42

Formula

C17H11F3N4OS2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Mycro2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mycro2
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HY-126979
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