2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Neuronal Signaling Others
  3. Endogenous Metabolite iGluR Amino Acid Derivatives
  4. N,N-Dimethylglycine hydrochloride

N,N-Dimethylglycine hydrochloride  (Synonyms: N,N-二甲基甘氨酸盐酸盐; Dimethylglycine hydrochloride; DMG hydrochloride; N-Methylsarcosine hydrochloride)

目录号: HY-W001158 纯度: ≥97.0%
COA 产品使用指南 技术支持

N,N-Dimethylglycine (Dimethylglycine) hydrochloride 是一种天然的 N-甲基化甘氨酸，是一种营养补充剂，可作为 NMDAR 甘氨酸位点部分激动剂。N,N-Dimethylglycine hydrochloride 是一种甲基供体，可以提高免疫力，作为抗氧化剂防止氧化应激，并清除过量的自由基。N,N-Dimethylglycine hydrochloride 具有抗抑郁样和表面活性剂的作用。

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N,N-Dimethylglycine hydrochloride Chemical Structure

N,N-Dimethylglycine hydrochloride Chemical Structure

CAS No. : 2491-06-7

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Other Forms of N,N-Dimethylglycine hydrochloride:

N,N-Dimethylglycine hydrochloride 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

N,N-Dimethylglycine (40mg/mL) hydrochloride 在 DPPH 自由基清除实验、ABTS+ 自由基清除实验和 H2O2 清除实验中分别展现出 88.40%、98.90% 和 87.58% 的清除活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N,N-Dimethylglycine hydrochloride 相关抗体:
体内研究
(In Vivo)

N,N-Dimethylglycine (30-100 mg/kg；腹腔注射；每天 2 次；14 天) hydrochloride 在雄性 ICR 小鼠中预防了重复药物暴露诱导的行为异常和突触功能障碍[1]。
N,N-Dimethylglycine (12 mg/0.3 mL 无菌生理盐水；灌胃；单次；1 小时后皮下注射) hydrochloride 在雄性昆明小鼠中改善了小肠组织学形态，增强了抗氧化系统，减少了氧化损伤，增加了抗氧化相关基因的表达[2]。
N,N-Dimethylglycine (12 mg/0.3 mL 无菌生理盐水；灌胃；每天 2 次；28 天) hydrochloride 在雄性昆明小鼠中提高了体重、肝脏和脾脏的器官比例，增强了血清和肝脏的抗氧化能力，降低了血清谷丙转氨酶 (ALT) 和谷草转氨酶 (AST) 活性以及血清和肝脏中丙二醛 (MDA) 含量[3]。
N,N-Dimethylglycine (12 mg/0.3 mL 无菌生理盐水；灌胃；每天 2 次；28 天) hydrochloride 在雄性昆明小鼠 Lipopolysaccharides (LPS) (HY-D1056) 诱导的氧化应激模型中降低了血清 ALT 和 AST 含量、肝脏线粒体中 ROS 水平，增加了肝脏线粒体抗氧化能力和线粒体膜电位 (MMP) 水平[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (body weight 10-12 g, 3-week- old) + Repeated drug exposure (20 mg/kg, i.p., twice daily for 14 days)[1].
Dosage: 30 mg/kg, 100 mg/kg
Administration: Intraperitoneal injection, 20 min prior to each drug injection, twice a day, 14 days.
Result: Prevented the drug-induced memory impairments in novel location recognition test (NLRT) and novel object recognition test (NORT), social withdrawal in reciprocal social interaction test, and enhanced head twitch response induced by serotonergic hallucinogen.
Animal Model: Male Kunming mice (weight 20-25 g, 40 days old) + Indomethacin injection (10 mg/kg BW)[2].
Dosage: 12 mg/0.3 mL sterile saline
Administration: Orally gavage; single dose; and then subcutaneous injection 1 hour later.
Result: Improved the histological morphology of the small intestine. Enhanced the antioxidant system, reduced oxidative damage, and increased the expression of antioxidant-related genes in the small intestine and its mitochondria compared with the indomethacin-treated group2.
Animal Model: Male Kunming mice (weight 20-25 g, 40 days old) + Lipopolysaccharides (LPS) injection (100 μg/kg body weight)[3].
Dosage: 12 mg/0.3 mL sterile saline
Administration: Orally gavage; twice a day; 28 days.
Result: Significantly decreased the serum ALT and AST content, ROS level, and expression of liver antioxidant gene MnSOD, Gpx1, Sirt1.
Significantly increased the hepatic mitochondrial antioxidant capacity (MnSOD, GSH, GPx, GR) and MMP level compared with the LPS-treated group.
分子量

139.58

同用名

N,N-二甲基甘氨酸盐酸盐; Dimethylglycine hydrochloride; DMG hydrochloride; N-Methylsarcosine hydrochloride

Formula

C4H10ClNO2
CAS 号
性状

固体

颜色

White to off-white

中文名称

N,N-二甲基甘氨酸盐酸盐； N-甲基肌氨酸盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (358.22 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 7.1644 mL 35.8218 mL 71.6435 mL
5 mM 1.4329 mL 7.1644 mL 14.3287 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (285 KB) HNMR (87 KB)

产品使用指南 (1538 KB)
参考文献

N,N-Dimethylglycine hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.1644 mL 35.8218 mL 71.6435 mL 179.1088 mL
5 mM 1.4329 mL 7.1644 mL 14.3287 mL 35.8218 mL
10 mM 0.7164 mL 3.5822 mL 7.1644 mL 17.9109 mL
15 mM 0.4776 mL 2.3881 mL 4.7762 mL 11.9406 mL
20 mM 0.3582 mL 1.7911 mL 3.5822 mL 8.9554 mL
25 mM 0.2866 mL 1.4329 mL 2.8657 mL 7.1644 mL
30 mM 0.2388 mL 1.1941 mL 2.3881 mL 5.9703 mL
40 mM 0.1791 mL 0.8955 mL 1.7911 mL 4.4777 mL
50 mM 0.1433 mL 0.7164 mL 1.4329 mL 3.5822 mL
60 mM 0.1194 mL 0.5970 mL 1.1941 mL 2.9851 mL
80 mM 0.0896 mL 0.4478 mL 0.8955 mL 2.2389 mL
100 mM 0.0716 mL 0.3582 mL 0.7164 mL 1.7911 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N-Dimethylglycine2491-06-7DimethylglycineDMGN-MethylsarcosineN,N-二甲基甘氨酸盐酸盐 N-甲基肌氨酸盐酸盐Endogenous MetaboliteiGluRAmino Acid DerivativesIonotropic glutamate receptorsNMDAR Agonistnutrient supplementantioxidantmethyl donor,Inhibitorinhibitorinhibit

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