2. Metabolic Enzyme/Protease Anti-infection
  3. Glycosidase Flavivirus Parasite
  4. N-Nonyldeoxynojirimycin

N-Nonyldeoxynojirimycin  (Synonyms: NN-DNJ; Nonyl-DNJ)

目录号: HY-107532 纯度: ≥98.0%
COA 产品使用指南 技术支持

N-Nonyldeoxynojirimycin (NN-DNJ) 是一种具疏水长链的脱氧野尻霉素衍生物。N-Nonyldeoxynojirimycin 是口服有效的酸性 α-葡萄糖苷酶 (IC50: 0.42 μM) 和 α-1,6-葡萄糖苷酶 (IC50: 8.4 μM) 的抑制剂。N-Nonyldeoxynojirimycin 具有抑制糖原分解、抗病毒和抗肿瘤的活性。N-Nonyldeoxynojirimycin 还具有杀虫的作用，对 Bemisia tabaci 成虫的 LD50 为 5 mM。

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Custom Peptide Synthesis

N-Nonyldeoxynojirimycin Chemical Structure

N-Nonyldeoxynojirimycin Chemical Structure

CAS No. : 81117-35-3

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5 mg ￥1700
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10 mg ￥2700
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25 mg ￥5400
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N-Nonyldeoxynojirimycin 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-Nonyldeoxynojirimycin (NN-DNJ) is a deoxynojirimycin derivative with a hydrophobic long chain. N-Nonyldeoxynojirimycin is an orally active inhibitor of acid α-glucosidase (IC50: 0.42 μM) and α-1,6-glucosidase (IC50: 8.4 μM). N-Nonyldeoxynojirimycin has activities of inhibiting glycogen breakdown, anti-virus and anti-tumor. N-Nonyldeoxynojirimycin also has insecticidal effects, with an LD50 of 5 mM for adults of Bemisia tabaci[1][2][3][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW IC50
4 μM
Compound: 9
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay
Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay
[PMID: 24900289]
SH-SY5Y IC50
0.003 μM
Compound: 2; D-NNDNJ
Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay
Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay
[PMID: 31075609]
SH-SY5Y IC50
5.6 μM
Compound: 2; D-NNDNJ
Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay
Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay
[PMID: 31075609]
Vero CC50
> 40 μM
Compound: NNDNJ
Cytotoxicity against african green monkey Vero cells by MTT assay
Cytotoxicity against african green monkey Vero cells by MTT assay
[PMID: 19223639]
Vero EC50
1.1 μM
Compound: NNDNJ
Antiviral activity against Dengue virus C infected in african green monkey Vero cells assessed as reduction in viral titer after 72 hrs by plaque reduction assay
Antiviral activity against Dengue virus C infected in african green monkey Vero cells assessed as reduction in viral titer after 72 hrs by plaque reduction assay
[PMID: 19223639]
体外研究
(In Vitro)

N-Nonyldeoxynojirimycin (0-200 μM; 3 天) 在 MDBK 细胞中抑制了传染性牛病毒性腹泻病毒 (BVDV) 的分泌，IC50 为 2.5 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N-Nonyldeoxynojirimycin 相关抗体:
体内研究
(In Vivo)

N-Nonyldeoxynojirimycin (10-250 mg/kg; 饮食给药; 1-120 天) 在小鼠的肝脏和骨骼肌中可诱导糖原积累[2]。
N-Nonyldeoxynojirimycin (饮食给药) 在荷有 CT-2A 肿瘤的 C57BL/6 小鼠中，与 Miglustat (HY-17020) 相比，以更少的副作用减少肿瘤生长和神经节苷脂含量[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice[2]
Dosage: 250 mg/kg/day for 1-120 days or 10-250 mg/kg/day for 30 days
Administration: Dietary administration
Result: Significantly increased liver glycogen concentration to 526 mmol/g wet weight in fasted mice at 250 mg/kg/day for 30 days, with effects plateauing at 50 days and persisting for 120 days. Glycogen accumulation was also observed in gastrocnemius muscle of both fed and fasted mice, and occasional glycogen deposition was seen in heart sections.
Induced dose-dependent liver glycogen inhibition at lower doses (≥50 mg/kg/day), with significant effects at 50 mg/kg/day .
分子量

289.41

Formula

C15H31NO4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (172.77 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4553 mL 17.2765 mL 34.5531 mL
5 mM 0.6911 mL 3.4553 mL 6.9106 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (282 KB)

产品使用指南 (1538 KB)
参考文献

N-Nonyldeoxynojirimycin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4553 mL 17.2765 mL 34.5531 mL 86.3826 mL
5 mM 0.6911 mL 3.4553 mL 6.9106 mL 17.2765 mL
10 mM 0.3455 mL 1.7277 mL 3.4553 mL 8.6383 mL
15 mM 0.2304 mL 1.1518 mL 2.3035 mL 5.7588 mL
20 mM 0.1728 mL 0.8638 mL 1.7277 mL 4.3191 mL
25 mM 0.1382 mL 0.6911 mL 1.3821 mL 3.4553 mL
30 mM 0.1152 mL 0.5759 mL 1.1518 mL 2.8794 mL
40 mM 0.0864 mL 0.4319 mL 0.8638 mL 2.1596 mL
50 mM 0.0691 mL 0.3455 mL 0.6911 mL 1.7277 mL
60 mM 0.0576 mL 0.2879 mL 0.5759 mL 1.4397 mL
80 mM 0.0432 mL 0.2160 mL 0.4319 mL 1.0798 mL
100 mM 0.0346 mL 0.1728 mL 0.3455 mL 0.8638 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Nonyldeoxynojirimycin81117-35-3NN-DNJ Nonyl-DNJGlycosidaseFlavivirusParasiteMDBKCT-2AInhibitorinhibitorinhibit

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