2. Others Membrane Transporter/Ion Channel Anti-infection Apoptosis Immunology/Inflammation Stem Cell/Wnt
  3. Reference Standards Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
  4. Nigericin (Standard)

Nigericin (Standard)  (Synonyms: 尼日利亚霉素 (Standard))

目录号: HY-127019R
产品使用指南 技术支持

Nigericin (Standard)是 Nigericin 的分析标准品。本产品用于研究及分析应用。Nigericin 是一种抗生素 (antibiotic)，源自 Streptomyces hygroscopicus，充当 K+/H+ 离子载体 (K+/H+ ionophore)，促进 K+/H+ 跨线粒体膜交换。Nigericin 是 NLRP3 的激活剂。Nigericin 通过降低细胞内 pH (pHi) 和 Wnt/β-catenin 通路信号而显示出良好的抗癌活性。Nigericin 在 TNBC 中通过 caspase 1/GSDMD 途径诱导细胞焦亡 (pyroptosis)[3] 。

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Nigericin (Standard)

Nigericin (Standard) Chemical Structure

CAS No. : 28380-24-7

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Nigericin (Standard) 相关抗体

Top Publications Citing Use of Products

查看 NOD-like Receptor (NLR) 亚型特异性产品:

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NLRP3 NLRP1 NOD1 NOD2

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

查看 Wnt 亚型特异性产品:

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Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nigericin (Standard) is the analytical standard of Nigericin (HY-127019). This product is intended for research and analytical applications. Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC[1][2][3][4][5][6][7].

IC50 & Target

K+/H+ ionophore[1]
分子量

724.96

Formula

C40H68O11
CAS 号
中文名称

尼日利亚霉素 (Standard)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nigericin (Standard) 相关分类

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Keywords:

Nigericin (Standard)28380-24-7尼日利亚霉素 (Standard)Reference StandardsPotassium ChannelNOD-like Receptor (NLR)BacterialAntibioticPyroptosisWntβ-cateninKcsABeta cateninCancerInhibitorinhibitorinhibit

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