2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Nociceptin(1-7)

Nociceptin(1-7) 是 Nociceptin (HY-P0183) 的 N 端生物活性片段。Nociceptin(1-7) 是一种有效的 ORL1 (NOP) 受体激动剂，具有缓解疼痛活性。Nociceptin (1-7) 联合 Nociceptin 可降低体内对痛觉的敏感。

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Custom Peptide Synthesis

Nociceptin(1-7) Chemical Structure

Nociceptin(1-7) Chemical Structure

CAS No. : 178249-42-8

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Other Forms of Nociceptin(1-7):

Nociceptin(1-7) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo[1].

体内研究
(In Vivo)

Nociceptin (1-7) (intrathecal injection; 150–1200  nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0 fmol), nociceptin-induced hyperalgesia is significantly reduced[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 150–1200  nmol
Administration: Intrathecal injection; single dose
Result: Co-treatment with nociceptin could reduce hyperalgesia.
分子量

655.70

Formula

C31H41N7O9
CAS 号
Sequence

Phe-Gly-Gly-Phe-Thr-Gly-Ala
Sequence Shortening

FGGFTGA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nociceptin(1-7) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nociceptin(1-7)178249-42-8Opioid ReceptorNociceptivethermal threshold,?hyperalgesiaspinal cordorphan opioid-like receptorAnalgesiahyperalgesiametaboliteN-terminalfragmentInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P1319
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