1. Apoptosis
  2. Apoptosis
  3. NS3694

NS3694 

目录号: HY-108356
产品使用指南

NS3694 是一种二芳基脲化合物,是一种凋亡体抑制剂。NS3694 抑制凋亡小体形成和半胱天冬酶活化。

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NS3694 Chemical Structure

NS3694 Chemical Structure

CAS No. : 426834-38-0

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  • 生物活性

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  • 参考文献

生物活性

NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation[1].

体外研究
(In Vitro)

When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed[1].
NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells[1].
NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 10 μM, 50 μM, 100 μM
Incubation Time: 120 min
Result: Inhibited cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.
分子量

358.70

Formula

C15H10ClF3N2O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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NS3694
目录号:
HY-108356
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