2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis Topoisomerase
  4. NSC 727357

NSC 727357 是一种 DNA 嵌入剂和拓扑异构酶 (topoisomerase) 抑制剂，具有抗肿瘤活性。NSC 727357 能够抑制细胞增殖并诱导 G1 期阻滞。NSC 727357 可用于癌症研究，例如黑色素瘤。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

NSC 727357

NSC 727357 Chemical Structure

CAS No. : 910229-23-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

NSC 727357 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSC 727357 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. NSC 727357 can inhibit cells proliferation and induce G1 phase arrest. NSC 727357 can be used for the research of cancer, such as melanoma[1].

体外研究
(In Vitro)

NSC 727357 (<10 μM) 诱导 Top1 切割复合物形成，高浓度 (≥10 μM) 抑制 Top1 催化活性；同时诱导少量 Top2-DNA 切割复合物[1]。
NSC 727357 可嵌入 DNA 并使其超螺旋化[1]。
NSC 727357 (0.1-5 μM, 18 h) 使 HT29 细胞停滞在 G1 期[1]。
NSC 727357 对 NCI-60 细胞系具有强效抗增殖活性，GI50 值为 0.067 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NSC 727357 相关抗体:
体内研究
(In Vivo)

NSC 727357 (13.4-30 mg/kg，腹腔注射，在肿瘤植入后第 7 天开始，每天一次，持续 5 天) 可抑制携带 LOX-IMVI 黑色素瘤异种移植物的 nu/nuNCr 小鼠中的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nu/nuNCr mice bearing LOX-IMVI melanoma xenografts[1]
Dosage: 13.4, 20, and 30 mg/kg
Administration: Intraperitoneally injection, starting on day 7 after tumor implantation, daily for 5 days
Result: Reducd median tumor weight by 24%, 33%, and 56%.
分子量

648.75

Formula

C41H36N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NSC 727357 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 727357910229-23-1NSC727357NSC-727357DNA/RNA SynthesisTopoisomeraseDNA intercalatorcancermelanomaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
NSC 727357
目录号：
HY-105293
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z