NSC15520 

NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling^[1].

NSC15520 (10- 0.5 -10-3.5 M) 抑制 RPA 与 GST-p53 肽的相互作用，IC₅₀ 为 10 μM^[1]。
Nsc15520 (0-400 μM; 5 min) 抑制螺旋不稳定活性^[1]。
Nsc15520 (0-400 μM; 5 min) 抑制 RPA 结合 dsDNA 30-mer^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

418.52

C₂₄H₃₄O₆

730960-98-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Glanzer JG, et al. Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods. Bioorg Med Chem. 2011 Apr 15;19(8):2589-95.  [Content Brief]