2. Epigenetics
  3. Histone Methyltransferase
  4. NSD2-PWWP1 ligand 1

NSD2-PWWP1 ligand 1 (compound 34) 是靶向 NSD2-PWWP1 结构域的小分子配体 (pIC50: 8.2)。NSD2 是具有组蛋白写入和组蛋白读取功能的大型多结构域蛋白，组蛋白甲基转移酶核受体结合 SET 结构域 2 (NSD2) 的水平失调后，可能导致多种血液和实体恶性肿瘤。NSD2-PWWP1 ligand 1 结合 NSD2 可减少其酶活性，抑制肿瘤发生。

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NSD2-PWWP1 ligand 1 Chemical Structure

NSD2-PWWP1 ligand 1 Chemical Structure

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NSD2-PWWP1 ligand 1 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSD2-PWWP1 ligand 1 (compound 34) is a small molecule ligand targeting the NSD2-PWWP1 domain (pIC50: 8.2). NSD2 is a large multidomain protein with histone writer and histone reader functions. Dysregulation of the levels of histone methyltransferase nuclear receptor binding SET domain 2 (NSD2) may lead to a variety of hematological and solid malignancies. NSD2-PWWP1 ligand 1 binds to NSD2, reducing its enzymatic activity and inhibiting tumorigenesis[1].

分子量

417.50

Formula

C25H27N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NSD2-PWWP1 ligand 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSD2-PWWP1 ligand 1Histone MethyltransferaseInhibitorinhibitorinhibit

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