2. Epigenetics TGF-beta/Smad
  3. PKC
  4. O-Desmethyl Midostaurin

O-Desmethyl Midostaurin  (Synonyms: CGP62221; O-Desmethyl PKC412)

目录号: HY-129491
COA 产品使用指南

摩尔计算器

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) 是 Midostaurin (HY-10230) 的活性代谢物，通过细胞色素 P450 肝酶代谢产生，可以作为 Midostaurin 在体内代谢的指标之一。Midostaurin 是一种多靶点蛋白激酶 (kinase) 抑制剂，IC50 范围为 22-500 nM。

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O-Desmethyl Midostaurin Chemical Structure

O-Desmethyl Midostaurin Chemical Structure

CAS No. : 740816-86-8

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规格 价格 是否有货
1 mg ￥7400
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Other Forms of O-Desmethyl Midostaurin:

O-Desmethyl Midostaurin 相关抗体

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查看 PKC 亚型特异性产品:

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

IC50 & Target

IC50: active metabolite of Midostaurin[1]
分子量

556.61

Formula

C34H28N4O4
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

O-Desmethyl Midostaurin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-Desmethyl Midostaurin740816-86-8CGP62221 O-Desmethyl PKC412CGP 62221CGP-62221PKCProtein kinase CactivemetabolitePKC412indicatorInhibitorinhibitorinhibit

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