1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. ODN 1982

ODN 1982 是一种非甲基化寡脱氧核苷酸,没有CpG基序,可用于制备 DNA 疫苗。ODN 1982 抑制 R-848 信号通路。ODN 1982 序列:5’-tccaggacttctctcaggtt-3’。

该游离形式化合物不稳定,推荐具有相同生物学活性的稳定盐形式 ODN 1982 sodium

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DNA, d(P-thio)(T-C-C-A-G-G-A-C-T-T-C-T-C-T-C-A-G-G-T-T)

ODN 1982 Chemical Structure

CAS No. : 207623-15-2

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1 mg ¥720
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5 mg ¥1780
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10 mg ¥2860
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生物活性

ODN 1982 is a unmethylated oligodeoxyribonucleotide (ODN) with no CpG motif, can be used to prepare DNA vaccines. ODN 1982 inhibits R-848 signaling. ODN 1982 sequence: 5’-tccaggacttctctcaggtt-3’[1][2].

体外研究
(In Vitro)

ODN 1982 (0.1、1 和 5 μM) 对表达 hTLR7 的 HEK293 细胞中的 NF-κB 诱导没有影响[2]
ODN 1982 (0.1-10 μM;24 小时) 与 Loxoribine 一起不会在中等背景以上诱导 IL-12p40,并且产生很少的 TNF+ 单核细胞[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

6364.10

CAS 号
性状

固体

颜色

White to off-white

Sequence

DNA, d(P-thio)(T-C-C-A-G-G-A-C-T-T-C-T-C-T-C-A-G-G-T-T)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ODN 1982
目录号:
HY-150729
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