2. Anti-infection
  3. SARS-CoV
  4. Ogalvibart

Ogalvibart  (Synonyms: C-135-LS; BMS-986414)

目录号: HY-145644

摩尔计算器

Ogalvibart (C-135-LS) 是一种人源抗 SARS-CoV-2 单克隆抗体 (IgG1 型)。Ogalvibart 可与 SARS-CoV-2 的刺突 (S) 糖蛋白受体结合域 (RBD) 结合。Ogalvibart 联合 C144LS 使用 (比例为 1:1) 具有良好的预防活性，能有效地阻断恒河猴疾病模型中 COVID19 的发展。

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Ogalvibart Chemical Structure

Ogalvibart Chemical Structure

CAS No. : 2599039-60-6

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Ogalvibart 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ogalvibart (C-135-LS) is a human anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Ogalvibart binds to the spike (S) glycoprotein receptor-binding domain (RBD) of SARS-CoV-2. Ogalvibart in combination with C144LS (1:1 ratio) shows good preventive activity and can effectively block the development of COVID19 in a rhesus monkey disease model[1].

IC50 & Target

SARS-CoV-2[1].
体内研究
(In Vivo)

Ogalvibart (C-135-LS; 10 mg/kg; 感染前 75 天给药) 联合 10 mg/kg 的 C144LS 时，能有效阻断恒河猴疾病模型中 COVID19 的发展[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rhesus macaques (3-11 years old)[1].
Dosage: 10 mg/kg (in combination with 10 mg/kg C144LS)
Administration: 75 days before infection
Result: Protected a subset of animals whose infectious challenge was 75 days post administration from disease.
Clinical Trial
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ogalvibart 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ogalvibart2599039-60-6C-135-LS BMS-986414BMS986414BMS 986414BMS-986414SARS-CoVSARS coronavirusCOVID19RBDspike (S) glycoproteinInhibitorinhibitorinhibit

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