2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Neuronal Signaling Anti-infection
  3. COX Reactive Oxygen Species (ROS) NO Synthase Keap1-Nrf2 Heme Oxygenase (HO) Amyloid-β Parasite
  4. Oleocanthal

Oleocanthal 是一种口服活性的酚类 seciridoid 化合物。Oleocanthal 可从橄榄油中提取。Oleocanthal 抑制 COX-1、COX-2，减少 ROS、NO，上调 Nrf-2 和 HO-1。Oleocanthal 减少 Aβ 沉积。Oleocanthal 对 L. major 前鞭毛体和无鞭毛体具有抗利什曼原虫活性，其 IC50 值分别为 18.7 和 87 μg/mL。Oleocanthal 对结肠癌、乳腺癌、肝癌和黑色素瘤具有抗癌活性。Oleocanthal 具有抗炎、神经保护。Oleocanthal 可用于阿尔茨海默症研究。

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Oleocanthal

Oleocanthal Chemical Structure

CAS No. : 289030-99-5

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Oleocanthal 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

查看 Heme Oxygenase (HO) 亚型特异性产品:

查看所有亚型
HO-1 HO-2

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oleocanthal is an orally active phenolic seciridoid compound. Oleocanthal can be extracted from olive oil. Oleocanthal inhibits COX-1 and COX-2, reduces ROS and NO, and upregulates Nrf-2 and HO-1. Oleocanthal reduces Aβ deposition. Oleocanthal exhibits anti-Leishmania activity against promastigotes and amastigotes of L. major, with IC50 values of 18.7 and 87 μg/mL, respectively. Oleocanthal exhibits anticancer activity against colon, breast, liver, and melanoma cancers. Oleocanthal also exhibits anti-inflammatory and neuroprotective properties. Oleocanthal can be used in Alzheimer's disease research[1][2][3][4][5][6].

IC50 & Target[1][2][3][4][5][6]

COX-1

 

COX-2

 

Leishmania

 

HO-1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDA-MB-231 IC50
15 μM
Compound: 1
Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay
[PMID: 23403296]
MDA-MB-231 IC50
7.5 μM
Compound: 1
Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound healing assay
Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound healing assay
[PMID: 23403296]
体外研究
(In Vitro)

Oleocanthal (25-100 μM) 可降低 LPS 刺激的小鼠腹膜巨噬细胞中的活性氧 (ROS)、亚硝酸盐和促炎细胞因子水平[1]。
Oleocanthal (1-25 μM；12 h) 可降低 LPS 诱导的 ATDC-5 软骨细胞中 NOS2 的合成和 NO 的产生[2]。
Oleocanthal (0-200 μg/mL；48-60 h) 可抑制 L. major 前鞭毛体和无鞭毛体的生长，其 IC50 值分别为 18.7 和 87 μg/mL[5]。
Oleocanthal 对 COX-1 和 COX-2 酶具有抑制活性[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Oleocanthal 相关抗体:

Western Blot Analysis[1]

Cell Line: murine peritoneal macrophages
Concentration: 25 μM, 50 μM, 100 μM
Incubation Time: 30 min
Result: Upregulated protein expression of Nrf-2 (25 μM: 1.57; 50 μM: 1.54; 100 μM: 1.63) and HO-1 (25 μM: 2.12; 50 μM: 2.24; 100 μM: 1.92).
体内研究
(In Vivo)

Oleocanthal (10 mg/kg/天；口服；每日一次；3 个月) 可改善 5xFAD 小鼠的代谢和行为表型，减少 Aβ 沉积，并改善血脑屏障功能[3]。
Oleocanthal (5 mg/kg b.w.；腹腔注射；每周 3 次；共 16 剂) 可抑制感染 L. major 的 BALB/c 小鼠的脚垫厚度，减少寄生虫负荷，并诱导 Th1 型免疫[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male wild-type C57BL/6J and 5xFAD mice (4 and 9 months of age)[3]
Dosage: 10 mg/kg
Administration: Oral gavage, daily, for 3 months
Result: Improved metabolic parameters (body weight, food and water intake, energy expenditure, etc.) and behavioral parameters (sleep patterns, anxiety-like behavior).
Reduced brain Aβ levels and IgG extravasation (improved BBB function).
Increased sleep hours and decreased movement related to anxiety-like behavior.
Clinical Trial
分子量

304.34

Formula

C17H20O5
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料

纯度: 99%

COA (281 KB)

产品使用指南 (1538 KB)
参考文献

Oleocanthal 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oleocanthal289030-99-5COXReactive Oxygen Species (ROS)NO SynthaseKeap1-Nrf2Heme Oxygenase (HO)Amyloid-βParasiteCyclooxygenaseNitric oxide synthasesNOSHeme Oxygenaseβ-amyloid peptideAβAbetaolive oilinflammationInhibitorinhibitorinhibit

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