2. Inhibitory Antibodies
  3. Ontuxizumab

Ontuxizumab  (Synonyms: MORAb-004)

目录号: HY-P99778 纯度: 99.85%
COA

摩尔计算器

Ontuxizumab (MORAb-004) 是一种具有抗肿瘤作用的 IgG1/κ 抗内皮素 (TEM-1 或 CD248) 的单克隆抗体。Ontuxizumab 可用于癌症的研究。

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Ontuxizumab Chemical Structure

Ontuxizumab Chemical Structure

CAS No. : 946415-62-9

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5 mg ￥7800
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Ontuxizumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer[1].

体外研究
(In Vitro)

Ontuxizumab (0-100 μg/mL；12 小时) 诱导 CD248 内化并剂量依赖性地降低了 46% 的人周皮细胞表面的 CD248[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ontuxizumab 相关抗体:
体内研究
(In Vivo)

Ontuxizumab (50 mg/kg；静脉注射，每天 5 次，连续 5 天) 在人 CD248 敲入小鼠显示抗肿瘤作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human CD248 knock-in mice[1]
Dosage: 50 mg/kg
Administration: Intravenous injection via tail vein; 50 mg/kg, 5 doses daily for 5 consecutive days
Result: Reduced tumor growth with a lower level of CD248 and α-SMA on neovasculature pericytes.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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  • Do most proteins show cross-species activity?

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Keywords:

Ontuxizumab946415-62-9MORAb-004MORAb004MORAb 004OthersantitumorIgG1/κinternalizationmiceInhibitorinhibitorinhibit

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