1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  2. EGFR
  3. Osimertinib-13C,d3

Osimertinib-13C,d3  (Synonyms: AZD-9291-13C,d3; Mereletinib-13C,d3)

目录号: HY-15772S1 纯度: 99.14%
COA 产品使用指南

Osimertinib-13C,d313C 标记的 Osimertinib 的氘代物。 Osimtinib (AZD9291) 是一种共价结合、具有口服活性、不可逆和突变选择性的 EGFR 抑制剂,其有效抑制 L858R (IC50=12 nM) 和 L858R/T790M (IC50=1 nM) EGFR。Osimtinib 解决了肺癌 T790M 突变介导的 EGFR 抑制剂耐药。

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Osimertinib-<sup>13</sup>C,d<sub>3</sub> Chemical Structure

Osimertinib-13C,d3 Chemical Structure

CAS No. : 2254100-49-5

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规格 价格 是否有货 数量
1 mg ¥13000
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Other Forms of Osimertinib-13C,d3:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Osimertinib-13C,d3 is the deuterium and 13C labeled Osimertinib. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

503.62

Formula

C2713CH30D3N7O2

CAS 号
非标记 CAS

1421373-65-0

性状

固体

颜色

White to off-white

中文名称

奥斯替尼 13C,d3;奥希替尼 13C,d3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
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