2. Immunology/Inflammation
  3. CD3
  4. Pavurutamab

Pavurutamab  (Synonyms: AMG-701)

目录号: HY-P99814 纯度: 95.70%
COA

摩尔计算器

Pavurutamab (AMG-701) 是一种抗 CD3 和抗 B 细胞成熟抗原 (BCMA) 的双特异性 T 细胞接合剂分子。Pavurutamab 在 Pacanalotamab (HY-P99798) 的基础上延长了半衰期。Pavurutamab 的 Fc 与分子偶联，可改善药代动力学参数。Pavurutamab 在免疫调节和多发性骨髓瘤 (MM) 中有潜在应用。

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Pavurutamab Chemical Structure

Pavurutamab Chemical Structure

CAS No. : 2250292-39-6

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规格 价格 是否有货 数量
1 mg ￥7500
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Pavurutamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on Pacanalotamab (HY-P99798). The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM)[1][2][3][4].

IC50 & Target

B cell maturation antigens, BCMA[1]
体外研究
(In Vitro)

Pavurutamab (0-10000 pM；48 h) 诱导 CD69+、CD25+ T 细胞活化和 IFNγ、TNFα、IL-2、IL-4、IL-6、IL-10 细胞因子分泌[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pavurutamab 相关抗体:
体内研究
(In Vivo)

Pavurutamab (0.02、0.2 和 2 mg/kg；静脉注射；第 3、8、13 天单剂量) 在小鼠异种移植模型中以时间和剂量依赖的方式减少肿瘤体积[5]。
Pavurutamab (0.005、0.05 和 0.5 mg/kg；静脉注射；每 5 天给药 6 次，持续 30 天) 在移植 L-363 多发性骨髓瘤 (MM) 细胞的 NOD/SCID 小鼠中，以时间和剂量依赖的方式减少肿瘤体积并提高存活率[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID mice transplanted with NCI-H929 MM cells mixed with PBMCs[5].
Dosage: 0.02, 0.2 and 2 mg/kg.
Administration: Intravenous injection; single dose on days 3, 8, 13.
Result: Reduced tumor volume.
Animal Model: NOD/SCID mice orthotopically transplanted with L-363 MM cells[5].
Dosage: 0.005, 0.05 and 0.5 mg/kg.
Administration: Intravenous injection; every 5 days for 6 administrations, starting from day 9 and lasting for 30 days.
Result: Reduced tumor volume and increased survival.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pavurutamab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pavurutamab2250292-39-6AMG-701AMG701AMG 701CD3Cluster of differentiation 3NOD/SCID miceCD69+ T cellCD25+ T cellMultiple MyelomaMMInhibitorinhibitorinhibit

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