2. PROTAC
  3. PROTACs
  4. PCC16 chloride

PCC16 chloride 是一种基于 CRBN 的 cp-PCC，其对 DHHC3 降解的 IC50 值为 102 nM。PCC16 chloride 具有抗肿瘤活性。(靶蛋白配体：HY-169235，连接物：HY-169236，E3 连接酶配体：HY-10984)。

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Custom Peptide Synthesis

PCC16 chloride

PCC16 chloride Chemical Structure

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PCC16 chloride 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

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  • 参考文献

生物活性

PCC16 chloride is a CRBN-based cp-PCC with an IC50 value of 102 nM for the degradation of DHHC3. PCC16 chloride has antitumor activity. (Target protein ligand: HY-169235, linker: HY-169236, E3 ligase ligand: HY-10984)[1].

分子量

4764.69

Formula

C206H322ClN67O60S
Sequence

{Rhodmine B}-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Gly-Ile-Gln-Asp-Thr-Asn-Ser-Lys-Lys-Gln-Ser-Asp-Thr-His-Leu-Glu-Glu-Thr-{Lys(pomalidomide-Suc-PEG2)}-NH2
Sequence Shortening

{Rhodmine B}-YGRKKRRQRRRCGIQDTNSKKQSDTHLEET-{Lys(pomalidomide-Suc-PEG2)}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PCC16 chloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCC16PCC 16PCC-16PROTACsCPPDHHC3antitumorInhibitorinhibitorinhibit

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产品名称：
PCC16 chloride
目录号：
HY-169232
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