1. Metabolic Enzyme/Protease Immunology/Inflammation
  2. Phosphodiesterase (PDE) Interleukin Related
  3. PDE4-IN-8

PDE4-IN-8 (Example 5) 是一种有效的 PDE4 抑制剂,对 PDE4B2 的 IC50为 0.93 nM。PDE4-IN-8 对 IL13、IL4、IFNy 的有微弱的抑制作用,IC50 分别为 4.04 nM, 36.33 nM, 2394 nM。

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PDE4-IN-8 Chemical Structure

PDE4-IN-8 Chemical Structure

CAS No. : 2415085-45-7

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

PDE4-IN-8 (Example 5) is a potent PDE4 inhibitor with an IC50 of 0.93 nM for PDE4B2.PDE4-IN-8 has little effect on IL13 (IC50=4.04 nM), IL4 (IC50=36.33 nM), IFNy (IC50=2394 nM)[1].

IC50 & Target[1]

PDE4B2

0.93 nM (IC50)

IL4

36.33 nM (IC50)

IL-13

4.04 nM (IC50)

分子量

327.18

Formula

C18H22BNO4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
PDE4-IN-8
目录号:
HY-144684
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