Pep2m 

Pep2m is a peptide receptor inhibitor. Pep2m inhibits the interaction between the C-terminus of the AMPA-type glutamate receptor (GluA2) subunit and N-ethylmaleimide-sensitive fusion protein (NSF). Pep2m prevents synaptic long-term depression (LTD). Pep2m can reduce postsynaptic currents in neurons, AMPA-mediated currents in cultured hippocampal neurons, and AMPA receptor surface expression^{[1][2][3][4][5]}.

Pep2m 在海马切片中的 CA1 锥体细胞中通过减少功能性 AMPAR 的数量，下降 EPSC 振幅，阻断 LTD^[1]。

Pep2m 在培养的海马神经元中降低对局部应用 AMPA 的电流响应^[2]。

pep2m 在存在河豚毒素 (TTX) 的情况下，可降低记录的 AMPA-微型兴奋性突触后电流 (mEPSC) 频率^[2]。

pep2m 降低含AMPA 型谷氨酸受体 (GluR2) 的 AMPA 受体的表面表达，但不会降低 NMDA 受体的表面表达和 AMPA 受体的内生长聚集^[2]。

Pep2m 在年轻 GluA2 KO 小鼠中不影响基础突触传递和低频刺激 (LFS) 诱导的 LTD，在成熟 GluA2 KO 小鼠中不影响基础突触传递但恢复了 LFS 诱导的 LTD^[3]。

Pep2m 减少 AMPA 诱发的放射性标记的去甲肾上腺素 ([³H]NA)，但不减少 AMPA 诱发的放射性标记的乙酰胆碱 ([³H]Ach) 释放^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pep2m (1 μL of 450 nM, ICV, once) 损害雄性 C57B6J 小鼠学习率和长期记忆表达^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1173.43

C₄₉H₉₂N₁₈O₁₃S

243843-42-7

Lys-Arg-Met-Lys-Val-Ala-Lys-Asn-Ala-Gln

KRMKVAKNAQ

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lüthi A, et al.Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron. 1999 Oct;24(2):389-99.  [Content Brief]

  [2]. Noel J, et al.Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron. 1999 Jun;23(2):365-76.  [Content Brief]

  [3]. Cao F, et al. Hippocampal Long-Term Depression in the Presence of Calcium-Permeable AMPA Receptors. Front Synaptic Neurosci. 2018 Nov 13;10:41.  [Content Brief]

  [4]. Conboy L, et al. Stress at learning facilitates memory formation by regulating AMPA receptor trafficking through a glucocorticoid action. Neuropsychopharmacology. 2010 Feb;35(3):674-85.  [Content Brief]

  [5]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96.  [Content Brief]