Phaseic acid  (Synonyms: 红花菜豆酸)

Phaseic acid is a Abscisic acid terpenoid catabolite that can able to activate a subset of Abscisic acid repectors. Phaseic acid is a plant hormone associated with photosynthesis arrest and abscission. Phaseic acid is the antagonist for NMDA-type glutamate receptor (NMDAR) that inhibits NMDAR currents with an IC₅₀ of 34.37 μM. Phaseic acid reduces intracellular calcium influx, and exhibits neuroprotective effect^[1][2].

Phaseic acid (10 µM, 3 h) 促进气孔关闭，减少鸭跖草 (Commelina communis) 叶片的水分蒸发^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Phaseic acid（50 mg/mL，脑室内注射，连续输注 3 天）可在小鼠脑动脉闭塞 (MCAO) 模型中改善缺血性脑损伤^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

280.32

C₁₅H₂₀O₅

24394-14-7

固体

White to off-white

红花菜豆酸

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Pedro L Rodriguez, et al. Abscisic Acid Catabolism Generates Phaseic Acid, a Molecule Able to Activate a Subset of ABA Receptors. Mol Plant. 2016 Nov 7;9(11):1448-1450.  [Content Brief]

  [2]. Hou ST, et al., Phaseic Acid, an Endogenous and Reversible Inhibitor of Glutamate Receptors in Mouse Brain. J Biol Chem. 2016 Dec 30;291(53):27007-27022.  [Content Brief]

  [3]. Sharkey TD, et al., Effects of phaseic Acid and dihydrophaseic Acid on stomata and the photosynthetic apparatus. Plant Physiol. 1980 Feb;65(2):291-7.  [Content Brief]