2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Apoptosis
  3. Histamine Receptor Apoptosis
  4. Pheniramine

Pheniramine  (Synonyms: Prophenpyridamine; Tripoton)

目录号: HY-B0971A
产品使用指南

摩尔计算器

Pheniramine (Prophenpyridamine;Tripoton) 是第一代组胺 H1 受体拮抗剂，作用于中枢神经系统 (CNS) ，产生镇静、助眠的作用。Pheniramine 也是安全、有效的局部麻醉剂，并有止痒作用。

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Pheniramine Chemical Structure

Pheniramine Chemical Structure

CAS No. : 86-21-5

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Pheniramine 的其他形式现货产品:

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Pheniramine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pheniramine (Prophenpyridamine;Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local anesthetic, with antipruritic effects[1][2][3][4].

IC50 & Target

H1 Receptor

1.01 mM (IC50)

体外研究
(In Vitro)

Pheniramine inhibits CYP2D6, the specific P450-isozymes, to delay metabolic time and prolong antihistaminic effects[1].
Pheniramine inhibits Ca2+ influx into BC3H-1 cells by inhibiting histamine with an IC50 value of 1.01 mM and regulates cellular Ca2+ transmembrane action[2].
Pheniramine (0.5, 1.0 mM; 24 h) induces cell apoptosis in human T-cell acute lymphoblastic leukemia cell lines[3].
Pheniramine (1 μM-1 mM; 12-48 h) inhibits cell proliferation in a time-dependent manner and shows inhibitory concentration IC50s of 550 μM (CCRF-CEM cells) and 420 μM (Jurkat cells), respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pheniramine 相关抗体:

Apoptosis Analysis[3]

Cell Line: Human T-cell acute lymphoblastic leukemia cell lines: CCRF-CEM and Jurkat ALL
Concentration: 0.5, 1.0 mM
Incubation Time: 24 hours
Result: Induced cells apoptosis with chromatin condenses and marginalizes, and nuclear debris spreaded into the cytoplasm.

Cell Viability Assay[3]

Cell Line: Human T-cell acute lymphoblastic leukemia cell lines: CCRF-CEM and Jurkat ALL
Concentration: 1 μM-1 mM
Incubation Time: 12, 24, 48 hours
Result: Inhibited cell proliferation and survival in a time- and dose-dependent manner.
体内研究
(In Vivo)

Pheniramine (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague–Dawley rats (300-350 g; male)[4]
Dosage: 0.30, 0.60, 0.90, 1.50, 1.75 μM
Administration: Intrathecal injection; one time
Result: Resulted the spinal block and displayed dose-dependent effect.
Showed 100% blockades in motor function, proprioception, and nociception, with full recoveryduration of action about 41, 56, and 88 min, respectively, at 1.75 μM.
分子量

240.34

Formula

C16H20N2
CAS 号
中文名称

非尼拉敏-d4EP杂质A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pheniramine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pheniramine86-21-5Prophenpyridamine Tripoton非尼拉敏-d4EP杂质AHistamine ReceptorApoptosisantiemeticsedativehypnoticlumbar punctureantipruriticcentral nervous systemCNSfirst-generationCa2+ influxhuman T-cell acute lymphoblastic leukemiaCCRF-CEMJurkat ALLBC3H-1spinal blockInhibitorinhibitorinhibit

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