2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Akt Apoptosis
  4. PI3Kδ-IN-24

PI3Kδ-IN-24 是一种选择性的 PI3Kδ 抑制剂 (IC50 = 0.1 nM)。PI3Kδ-IN-24 对 PI3Kδ 过表达的癌细胞系表现出显著的抗增殖作用。PI3Kδ-IN-24 降低 p-AKT 水平，诱导肿瘤细胞细胞周期停滞和凋亡 (apoptosis)。PI3Kδ-IN-24 可用于癌症研究，如弥漫性大 B 细胞淋巴瘤 (DLBCL)。

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PI3Kδ-IN-24

PI3Kδ-IN-24 Chemical Structure

CAS No. : 3051829-20-7

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PI3Kδ-IN-24 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3Kδ-IN-24 is a selective PI3Kδ inhibitor (IC50 = 0.1 nM). PI3Kδ-IN-24 exhibits significant antiproliferative effects against PI3Kδ-overexpressing cancer cell lines. PI3Kδ-IN-24 reduces p-AKT levels and induces cell cycle arrest and apoptosis in tumor cells. PI3Kδ-IN-24 is useful in cancer research, such as diffuse large B-cell lymphoma (DLBCL)[1].

IC50 & Target[1]

PI3Kδ

0.1 nM (IC50)

PI3Kγ

1.97 nM (IC50)

PI3Kα

97.85 nM (IC50)

体外研究
(In Vitro)

PI3Kδ-IN-24 (Compound M7) (72 小时) 对 SU-DHL-6 和 Pfeiffer 细胞生长有抑制作用，GI50 分别为 0.012 μM 和 0.068 μM；对 HCT-116、MCF-7 和 Raji 细胞则表现出较弱的抗增殖活性，GI50 分别为 1.20 μM、2.56 μM 和 6.83 μM[1]。
PI3Kδ-IN-24 (10-1000 nM，24 小时) 持续抑制 SU-DHL-6 细胞中的 AKT 磷酸化[1]。
PI3Kδ-IN-24 (10 μM，0.5 小时) 可提高 SU-DHL-6 细胞中内源性 PI3Kδ 的热稳定性[1]。
PI3Kδ-IN-24 (0.01-1 μM，24-72 小时) 将 SU-DHL-6 细胞阻滞在 G0/G1 期并引发其凋亡，但不会诱导 HEK293 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kδ-IN-24 相关抗体:

Western Blot Analysis[1]

Cell Line: SU-DHL-6 cells
Concentration: 10 nM, 33 nM, 100 nM, 333 nM, 1000 nM
Incubation Time: 24 h
Result: Reduced the expression level of p-AKT.

Cell Cycle Analysis[1]

Cell Line: SU-DHL-6 cells
Concentration: 0.01 μM, 0.1 μM, 1 μM
Incubation Time: 24 h
Result: Arrested the growth in the G0/G1 phase, blocked over 50 % in this phase at 0.1 μM, surpassing the efficacy of Idelalisib (HY-13026) at 10 μM.

Apoptosis Analysis[1]

Cell Line: SU-DHL-6 cells
Concentration: 0.01 μM, 0.1 μM, 1 μM
Incubation Time: 72 h
Result: Triggered apoptosis, induced apoptosis in approximately 60 % at 1 μM, surpassed Idelalisib in its capacity to promote apoptosis.
分子量

527.57

Formula

C28H29N7O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3Kδ-IN-24 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kδ-IN-243051829-20-7PI3KAktApoptosisPhosphoinositide 3-kinasePKBProtein kinase BInhibitorSU-DHL-6 cellsPfeiffer cellsinhibitorinhibit

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