2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Akt Apoptosis
  4. PI3Kδ-IN-11

PI3Kδ-IN-11 是一种高效且具有选择性的 PI3Kδ 抑制剂，IC50 为 27.5 nM。PI3Kδ-IN-11 剂量依赖性地阻断 PI3K/Akt 通路的活性。PI3Kδ-IN-11 可用于研究 B 细胞或 T 细胞相关的恶性肿瘤。

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PI3Kδ-IN-11 Chemical Structure

PI3Kδ-IN-11 Chemical Structure

CAS No. : 2413257-51-7

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PI3Kδ-IN-11 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC50 value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies[1].

IC50 & Target

PI3Kδ

27.5 nM (IC50)

体外研究
(In Vitro)

PI3Kδ-IN-11 (compound 15c) (0-10 μM; 48 hours) inhibits Raji and Ramos with IC50s of 8.5 μM and 5.4 μM, respectively[1].
PI3Kδ-IN-11 (0.2-15 μM; 0-48 hours) dampens the proliferation of Raji cells in a dose- and time-dependent manner[1].
PI3Kδ-IN-11 (5 μM; 24 hours) triggers 10.78% apoptosis of cells[1].
PI3Kδ-IN-11 (1-1000 nM; 24 hours) dose-dependently reduces the phosphorylation of Akt (S473)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kδ-IN-11 相关抗体:

Cell Viability Assay

Cell Line: Raji and Ramos[1]
Concentration: 0-10 μM
Incubation Time: 48 hours
Result: Inhibited Raji and Ramos with IC50s of 8.5 μM and 5.4 μM, respectively.

Cell Proliferation Assay

Cell Line: Raji[1]
Concentration: 0.2, 1, 4, 8, 10 and 15 μM
Incubation Time: 0, 12, 24, 36, 48 hours
Result: Dampened the proliferation of Raji cells in a dose- and time-dependent manner.

Apoptosis Analysis

Cell Line: Raji[1]
Concentration: 5 μM
Incubation Time: 24 hours
Result: Triggered 10.78% apoptosis of cells.

Western Blot Analysis

Cell Line: Raji[1]
Concentration: 1, 10, 100, 500 and 1000 nM
Incubation Time: 24 hours
Result: Dose-dependently reduced the phosphorylation of Akt (S473), illustrating that the activity of PI3K/Akt pathway was efficiently blocked.
分子量

431.49

Formula

C27H21N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3Kδ-IN-11 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kδ-IN-112413257-51-7PI3KAktApoptosisPhosphoinositide 3-kinasePKBProtein kinase BQuinazoline derivativesMalignanciesPI3K/Akt pathwaySelectivityRaji cellsRamos cellsInhibitorinhibitorinhibit

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