1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. PKC-theta inhibitor 1

PKC-theta inhibitor 1 

目录号: HY-126328
产品使用指南

PKC-theta inhibitor 1 是 PKCθ 抑制剂,Ki 值为 6 nM,在体内抑制 IL-2 产生,IC50 为 0.19 μM。PKC-theta inhibitor 1 减轻了多发性硬化小鼠模型中疾病症状。

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PKC-theta inhibitor 1 Chemical Structure

PKC-theta inhibitor 1 Chemical Structure

CAS No. : 1160501-81-4

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Description

PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. PKC-theta inhibitor 1 demonstrates a reduction of symptoms in a mouse model of multiple sclerosis[1].

IC50 & Target[1]

PKCθ

6 nM (Ki)

PKCδ

392 μM (Ki)

PKCα

1020 μM (Ki)

IL-2 production

0.19 μM (IC50)

Molecular Weight

348.32

Formula

C₁₇H₁₅F₃N₄O

CAS No.

1160501-81-4

SMILES

NCC1(C2=CC=CC(C3=C4C(NN=C4C(F)(F)F)=NC=C3)=C2)COC1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
PKC-theta inhibitor 1
目录号:
HY-126328
需求量:

PKC-theta inhibitor 1

Cat. No.: HY-126328