2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Immunology/Inflammation
  3. PPAR COX
  4. PPARγ agonist 19

PPARγ agonist 19 (Compound 5e) 是一种 PPARγ 激动剂。PPARγ agonist 19 对 COX-1 的 IC50 为 11.27 μM，对 COX-2 的 IC50 为 0.05 μM。PPARγ agonist 19 在大鼠半膈肌实验中增加葡萄糖摄取，且优于吡格列酮 (HY-13956)。PPARγ agonist 19 可减轻了 2 型糖尿病大鼠体内模型中的高血糖和胰岛素抵抗，而且还保护了其免受代谢功能障碍引起的肾脏和脂血损害。

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PPARγ agonist 19

PPARγ agonist 19 Chemical Structure

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PPARγ agonist 19 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PPARγ agonist 19 (Compound 5e) is a PPARγ agonist. PPARγ agonist 19 has an IC50 of 11.27 μM against COX-1 and an IC50 of 0.05 μM against COX-1. PPARγ agonist 19 increases glucose uptake in rat hemidiaphragm assay and is superior to pioglitazone (HY-13956). PPARγ agonist 19 alleviates hyperglycemia and insulin resistance in an in vivo model of type 2 diabetes in rats and protects against renal and lipidemia damage caused by metabolic dysfunction[1].

IC50 & Target

PPARγ

 

COX-1

11.27 μM (IC50)

COX-2

0.05 μM (IC50)

分子量

503.57

Formula

C20H17N5O5S3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PPARγ agonist 19 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARγ agonist 19PPARγ agonist19PPARγ agonist-19PPARCOXPeroxisome proliferator-activated receptorsCyclooxygenaseInhibitorinhibitorinhibit

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产品名称：
PPARγ agonist 19
目录号：
HY-176214
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