2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. PPI-GIT1/β-Pix interaction-IN-1

PPI-GIT1/β-Pix interaction-IN-1 

目录号: HY-152095
产品使用指南

摩尔计算器

PPI-GIT1/β-Pix interaction-IN-1 是一种口服有效的 GIT1/β-Pix 蛋白质-蛋白质相互作用 (PPI) 抑制剂，其 KD 值为 7.7 µM。PPI-GIT1/β-Pix interaction-IN-1 破坏 GIT/PIX 相互作用可以影响下游 Rho GTPase Rac1 和 Cdc42 的激活。 PPI-GIT1/β-Pix interaction-IN-1 抑制胃癌转移。

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PPI-GIT1/β-Pix interaction-IN-1 Chemical Structure

PPI-GIT1/β-Pix interaction-IN-1 Chemical Structure

CAS No. : 2070916-70-8

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PPI-GIT1/β-Pix interaction-IN-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer[1].

体外研究
(In Vitro)

PPI-GIT1/β-Pix interaction-IN-1 (compound 14-5-18; 0-50 μM) 抑制活细胞中 GIT1 和 β-Pix 的相互作用[1].< br/> PPI-GIT1/β-Pix interaction-IN-1 (0-50 μM; 24 小时; MGC803 细胞和 MKN45 细胞) 以剂量依赖的方式抑制胃癌细胞侵袭，破坏 GIT/PIX 相互作用可影响下游 Rho GTPase Rac1 和 Cdc42[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PPI-GIT1/β-Pix interaction-IN-1 相关抗体:

Western Blot Analysis[1]

Cell Line: MGC803 cells and MKN45 cells
Concentration: 0, 5, 20, and 50 μM
Incubation Time: 24 hours
Result: Suppressed the expression of GTP-Rac1 and GTP-Cdc42 in a dose-dependent manner.
体内研究
(In Vivo)
分子量

391.42

Formula

C23H21NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PPI-GIT1/β-Pix interaction-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPI-GIT1/β-Pix interaction-IN-12070916-70-8Rasprotein-protein interactionRho GTPase Rac1Cdc42gastric cancerMGC803MKN45Inhibitorinhibitorinhibit

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