2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Propantheline

Propantheline 是一种具有口服活性的 mAChR 拮抗剂。Propantheline 可用于研究平滑肌功能障碍、出汗过多、胃、肠或膀胱痉挛、以及不自主排尿的相关疾病研究。

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Propantheline Chemical Structure

Propantheline Chemical Structure

CAS No. : 298-50-0

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Propantheline 的其他形式现货产品:

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Propantheline 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Propantheline is an orally active mAChR antagonist. Propantheline can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination[1][2][3].

IC50 & Target

mAChR[1]
体外研究
(In Vitro)

Propantheline (10 μM-1 mM) decreases urinary bladder smooth muscle reactivity to Acetylcholine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Propantheline 相关抗体:
体内研究
(In Vivo)

Propantheline (oral administration, 10-300 mg/kg) decreased the fecal pellet count and the incidences diarrhea in restraint stress-induced bowel dysfunction rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Restraint stress-induced bowel dysfunction models in rats[3]
Dosage: 10-300 mg/kg
Administration: Oral administration
Result: Decreased the fecal pellet count with ED50 values of 41 mg/kg.
Dose-dependently decreased the incidences of diarrhea with ED50 values of 64 mg/kg.
Clinical Trial
分子量

368.49

Formula

C23H30NO3+
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Propantheline 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propantheline298-50-0mAChRMuscarinic acetylcholine receptorUrinationbladdercrampsIBSbowel dysfunctionInhibitorinhibitorinhibit

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