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  4. FGFR-1/CD331 FGFR
  5. FGFR-1
  6. FGFR-1 alpha (IIIc) 蛋白, Human (HEK293, His-Avi)

FGFR-1 alpha (IIIc) 蛋白, Human (HEK293, His-Avi)

目录号: HY-P77659
COA 产品使用指南

FGFR-1 α 是成纤维细胞生长因子的酪氨酸蛋白激酶受体,对胚胎发育、细胞增殖、分化和迁移至关重要。GnRH 对于中胚层模式、轴向组织、骨骼发生和神经系统发育至关重要。FGFR-1 alpha (IIIc) 蛋白, Human (HEK293, His-Avi) 是重组的 FGFR-1 α (IIIc) 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。FGFR-1 alpha (IIIc) 蛋白, Human (HEK293, His-Avi) 全长 353 个氨基酸,分子量为 65-85 kDa。

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规格 价格 是否有货 数量
20 μg ¥2100 In-stock
50 μg ¥4000 In-stock
100 μg ¥6400 In-stock
> 100 μg   询价  

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描述

FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is 353 a.a., with molecular weight of 65-85 kDa.

研究背景

FGFR-1 α 是一种酪氨酸蛋白激酶,作为成纤维细胞生长因子的细胞表面受体,在调节胚胎发育、细胞增殖、分化和迁移中发挥着关键作用。它对于正常的中胚层模式、胚胎发育过程中的正确轴向组织、骨骼发生以及促性腺激素释放激素 (GnRH) 神经系统的发育至关重要。配体结合后,FGFR-1 α 激活多个信号级联,磷酸化 PLCG1、FRS2、GAB1 和 SHB 等关键蛋白。这种激活导致通过 PLCG1 产生信号分子,如二酰基甘油和肌醇 1,4,5-三磷酸。此外,FRS2 的磷酸化会触发 GRB2、GAB1、PIK3R1 和 SOS1 的募集,介导 RAS、MAPK1/ERK2、MAPK3/ERK1、MAP 激酶信号通路和 AKT1 信号通路的激活。FGFR-1 α 还促进 SHC1、STAT1 和 PTPN11/SHP2 的磷酸化。在细胞核内,它增强 RPS6KA1 和 CREB1 的活性,有助于转录调节。FGFR-1 α 信号传导的下调通过 IL17RD/SEF 和 FGFR-1 α 泛素化、内化和降解发生。

生物活性

Immobilized Human FGFR1 alpha (IIIc) at 0.5 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-FGFR1 Antibody, hFc Tag with the EC50 of ≤12.9 ng/mL determined by ELISA.

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

P11362-7 (R22-E374)

基因 ID
蛋白结构
N-term
FGFR-1 alpha (IIIc) (R22-E374)
Accession # P11362-7
His-Avi
C-term
同用名
FGF R1a; FGFR1 alpha
分子量

65-85 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末

组分

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi)
目录号:
HY-P77659
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