1. 重组蛋白
  2. Cytokines and Growth Factors CD Antigens Receptor Proteins Enzymes & Regulators Biotinylated Proteins
  3. FGF Family Stem Cell CD Proteins Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. FGFR-3/CD333 FGFR
  5. FGFR-3
  6. FGFR-3 alpha (IIIc) 蛋白, Human (HEK293, His-Avi)

FGFR-3 alpha (IIIc) 蛋白, Human (HEK293, His-Avi)

目录号: HY-P78439
COA 产品使用指南

FGFR-3 蛋白是成纤维细胞生长因子的酪氨酸蛋白激酶受体,对细胞过程至关重要,特别是在软骨细胞、成骨细胞和内耳发育中。其影响涵盖正常骨骼发育和出生后骨矿化。FGFR-3 alpha (IIIc) 蛋白, Human (HEK293, His-Avi) 是重组的 FGFR-3 α (IIIc) 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。FGFR-3 alpha (IIIc) 蛋白, Human (HEK293, His-Avi) 全长 353 个氨基酸,分子量为 65-75 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
20 μg ¥1800 In-stock
50 μg ¥3400 In-stock
100 μg ¥5400 In-stock
> 100 μg   询价  

* Please select Quantity before adding items.

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) is 353 a.a., with molecular weight of 65-75 kDa.

研究背景

FGFR-3蛋白是一种酪氨酸蛋白激酶,作为成纤维细胞生长因子的细胞表面受体,在细胞增殖、分化和凋亡的调节中发挥着重要作用。其在调节软骨细胞分化、增殖和凋亡方面的意义尤其显着,有助于正常的骨骼发育。此外,FGFR-3 在成骨细胞的成骨和出生后骨矿化中发挥着至关重要的作用,同时还促进软骨细胞的凋亡。除了在正常发育中的作用之外,FGFR-3 还参与内耳发育,并对维生素 D 代谢的调节具有影响。配体结合后,FGFR-3 激活多个信号级联反应,包括 PLCG1、CBL 和 FRS2 的磷酸化。这种激活导致细胞信号分子的产生,例如二酰甘油和肌醇 1,4,5-三磷酸。此外,FRS2 的磷酸化会触发 GRB2、GAB1、PIK3R1 和 SOS1 的募集,介导 RAS、MAPK1/ERK2、MAPK3/ERK1、MAP 激酶信号通路和 AKT1 信号通路的激活。导致组成型激酶激活或损害正常 FGFR3 成熟、内化和降解的突变会导致信号传导异常。FGFR3 的过表达或组成型激活可促进 PTPN11/SHP2、STAT1、STAT5A 和 STAT5B 的激活。此外,分泌的异构体 3 保留了结合 FGF1 和 FGF2 的能力,可能干扰 FGF 信号传导。

生物活性

Immobilized Human FGFR3 alpha (IIIc) at 0.5 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of ≤11.7 ng/mL determined by ELISA.

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

P22607 (E23-G375)

基因 ID
蛋白结构
N-term
FGFR-3 alpha (IIIc) (E23-G375)
Accession # P22607
His-Avi
C-term
同用名
ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4
分子量

65-75 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末

组分

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi)
目录号:
HY-P78439
需求量: