2. 重组蛋白
  3. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  4. Ephrin/Eph Family Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. Eph Receptors
  6. EphB4
  7. EphB4 蛋白, Mouse (HEK293, Fc)

EphB4 蛋白, Mouse (HEK293, Fc)

目录号: HY-P73004
产品使用指南

Ephb4 蛋白是一种受体酪氨酸激酶，在血管生成和发育中发挥着关键作用。Ephb4 蛋白的失调与癌症和心血管疾病等疾病有关。靶向 Ephb4 蛋白可能通过调节血管生成、抑制肿瘤生长和控制心血管并发症，为这些疾病提供潜在的治疗干预。EphB4 蛋白, Mouse (HEK293, Fc) 是重组的 EphB4 蛋白，由 HEK293 表达，带有 C-hFc 标签。EphB4 蛋白, Mouse (HEK293, Fc) 全长 539 个氨基酸，分子量约为 ~110 kDa。

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描述

Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB4 Protein, Mouse (HEK293, Fc) is 539 a.a., with molecular weight of ~110 kDa.
研究背景

Ephb4 蛋白是一种受体酪氨酸激酶，与邻近细胞上的跨膜肝配蛋白-B 配体表现出混杂结合，启动接触依赖性双向信号传导。这导致受体下游的正向信号传导和肝配蛋白配体下游的反向信号传导。至关重要的是，Ephb4 蛋白与其同源配体 EFNB2 一起调节细胞粘附和迁移，在心脏形态发生、血管生成、血管重塑和通透性中发挥关键作用。值得注意的是，EPHB4 介导的前向信号传导控制细胞排斥和与表达 EFNB2 的细胞的分离。
种属

Mouse
表达系统

HEK293
标签

C-hFc
蛋白编号

P54761-1 (M1-A539)
基因 ID

13846  [NCBI]
蛋白结构
N-term
EphB4 (M1-A539)
Accession # P54761-1
hFc
C-term
同用名
Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11
氨基酸序列

MELRALLCWASLATALEETLLNTKLETADLKWVTYPQAEGQWEELSGLDEEQHSVRTYEVCDMKRPGGQAHWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASRSCKETFTVFYYESEADTATAHTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCSWLITNLTYFPETVPRELVVPVAGSCVANAVPTANPSPSLYCREDGQWAEQQVTGCSCAPGYEAAESNKVCRACGQGTFKPQIGDESCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSPCTTPPSAPRSVVHHLNGSTLRLEWSAPLESGGREDLTYAVRCRECRPGGSCLPCGGDMTFDPGPRDLVEPWVAIRGLRPDVTYTFEVAALNGVSTLATGPPPFEPVNVTTDREVPPAVSDIRVTRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLA

分子量

Approximately 110 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

EphB4 Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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