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PU 23 

目录号: HY-136217
产品使用指南

PU 23 是一种多药抗性蛋白 4 (MRP4) 抑制剂,可降低抗肿瘤剂 6-Mercaptopurine 的耐药性。

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PU 23 Chemical Structure

PU 23 Chemical Structure

CAS No. : 817635-93-1

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Description

PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine[1].

In Vitro

6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 2.81 and 14.11 μM, respectively. The combination of PU 23 (Cpd23) and 6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 1.84 and 6.06 μM, respectively[1].
Preincubation of HEK293/MRP4 cells with PU 23 (50 μM) for 2 h also significantly increases the amount of 6-MP in cells[1].

Molecular Weight

425.52

Formula

C₂₁H₁₉N₃O₃S₂

CAS No.

817635-93-1

SMILES

O=C(NC(NC1=CC=C(S(=O)(NCC2=CC=CC=C2)=O)C=C1)=S)C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PU 23PU23PU-23OthersmultidrugresistanceproteinMRP46-MercaptopurineInhibitorinhibitorinhibit

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产品名称:
PU 23
目录号:
HY-136217
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